炎症性肠病的药物治疗进展：溃疡性结肠炎

Update on medical management of inflammatory bowel disease: ulcerative colitis.

作者信息

Hanauer S B

机构信息

Section of Gastroenterology and Nutrition, University of Chicago, Pritzker School of Medicine, Chicago, IL, USA.

出版信息

Rev Gastroenterol Disord. 2001;1(4):169-76.

PMID:12120183

Abstract

Significant advances have been made regarding our understanding of the etiopathogenesis of inflammatory bowel disease. This review focuses on the most recent applications of medical therapy for ulcerative colitis. Therapeutic approaches continue to evolve regarding inductive and maintenance strategies with oral and topical aminosalicylates, systemic and non-systemic corticosteroids, and cyclosporine and alternative immunomodulators. As further investigations continue to discern microbiological and immunoinflammatory targets, future therapies may include both probiotics and novel biological agents.

摘要

在我们对炎症性肠病的病因发病机制的理解方面已经取得了重大进展。本综述重点关注溃疡性结肠炎医学治疗的最新应用。关于口服和局部用氨基水杨酸类药物、全身和非全身用皮质类固醇以及环孢素和替代免疫调节剂的诱导和维持策略，治疗方法仍在不断发展。随着进一步的研究继续识别微生物学和免疫炎症靶点，未来的治疗可能包括益生菌和新型生物制剂。