Grassi M, Raffa S, Damiani V C, Fontana M
Università degli Studi di Roma La Sapienza, Istituto di Idrologia Medica.
Clin Ter. 1995 May;146(5):327-41.
Authors synthetically remind epidemiology, eziopathogenesis and clinic of ulcerative colitis; they after describe the drugs employed in therapy of disease, stressing the mechanism of action, efficacy, collateral effects. Authors remember the choice of cortisonic therapy in the acute and severe periods of disease and the specific activity of salazopyrine and its metabolite 5-aminosalycilic acid in the ulcerative colitis and refer about the use of drugs as immunodepressors, fatty acids omega 3, zileuton, short chain fatty acids. Practical patterns of therapy in the diverse stages and clinical forms of the disease are exposed.
作者综合回顾了溃疡性结肠炎的流行病学、病因发病机制和临床情况；随后描述了用于治疗该疾病的药物，强调其作用机制、疗效和副作用。作者提及了在疾病急性期和严重期皮质类固醇疗法的选择，以及柳氮磺胺吡啶及其代谢产物5-氨基水杨酸在溃疡性结肠炎中的特殊活性，并介绍了免疫抑制剂、ω-3脂肪酸、齐留通、短链脂肪酸等药物的使用。文中阐述了该疾病不同阶段和临床类型的实际治疗模式。
