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多胺对核糖核酸合成的调节。精胺逆转甲基乙二醛双（脒腙）对兔心脏核糖核酸合成和组蛋白乙酰化的抑制作用。

Regulation of ribonucleic acid synthesis by polyamines. Reversal by spermine of inhibition by methylglyoxal bis(guanylhydrazone) of ribonucleic acid synthesis and histone acetylation in rabbit heart.

作者信息

Caldarera C M, Casti A, Guarnier C, Moruzzi G

出版信息

Biochem J. 1975 Oct;152(1):91-8. doi: 10.1042/bj1520091.

DOI:10.1042/bj1520091

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1172443/

Abstract

The relationship between polyamines and RNA synthesis was studied by considering the action of spermine on histone acetylation in perfused heart. In addition, the effect of methylglyoxal bis(guanylhydrazone), inhibitor of putrescine-activated S-adenosylmethionine decarboxylase activity, on RNA and polyamine specific radioactivity and on acetylation of histone fractions was also investigated in perfused heart. Different concentrations of spermine and/or methylglyoxas bis(guanylhydrazone) were injected into the heart, 15 min after beginning the perfusion. The results demonstrate that spermine stimulates the specific radioactivity of RNA of subcellular fractions. Acetylation of the arginine-rich histone fractions, involved in the regulation of RNA transcription, is enhanced by spermine. The perfusion with methylglyoxal bis(guanylhydrazone) causes a decrease in the specific radioactivity of polyamines and RNA, and in acetylation of histone fractions. However, spermine is able to reverse the methylglyoxal bis(guanylhydrazone) inhibition when injected simultaneously. From these results we may assume a possible role for spermine in the regulation of RNA transcription.

摘要

通过研究精胺对灌注心脏中组蛋白乙酰化的作用，探讨了多胺与RNA合成之间的关系。此外，还研究了甲基乙二醛双（胍腙）（腐胺激活的S-腺苷甲硫氨酸脱羧酶活性抑制剂）对灌注心脏中RNA和多胺比放射性以及组蛋白组分乙酰化的影响。在灌注开始15分钟后，将不同浓度的精胺和/或甲基乙二醛双（胍腙）注入心脏。结果表明，精胺可刺激亚细胞组分RNA的比放射性。参与RNA转录调控的富含精氨酸的组蛋白组分的乙酰化可被精胺增强。用甲基乙二醛双（胍腙）灌注会导致多胺和RNA的比放射性以及组蛋白组分的乙酰化降低。然而，当同时注射精胺时，它能够逆转甲基乙二醛双（胍腙）的抑制作用。从这些结果我们可以推测精胺在RNA转录调控中可能发挥的作用。