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活性炭和考来烯胺对扑热息痛吸收的减少:一种可能的治疗措施。

Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure.

作者信息

Dordoni B, Willson R A, Thompson R P, Williams R

出版信息

Br Med J. 1973 Jul 14;3(5871):86-7. doi: 10.1136/bmj.3.5871.86.

Abstract

The absorption of an oral 2-g dose of paracetamol was markedly reduced by the simultaneous oral administration of either activated charcoal or cholestyramine but was only slightly reduced when the adsorbents were given 60 minutes after the paracetamol. Since the absorption of a larger dose of the drug will probably be slow, the administration of adsorbents may be of value even when delayed several hours.

摘要

同时口服活性炭或考来烯胺可显著降低口服2克对乙酰氨基酚的吸收,但在对乙酰氨基酚给药60分钟后给予吸附剂时,吸收仅略有降低。由于较大剂量药物的吸收可能较慢,即使延迟数小时给药,吸附剂的使用可能仍有价值。

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本文引用的文献

1
The absorption characteristics of paracetamol tablets in man.对乙酰氨基酚片在人体中的吸收特性。
J Pharm Pharmacol. 1963 Jul;15:445-53. doi: 10.1111/j.2042-7158.1963.tb12812.x.
4
Acute paracetamol poisoning.对乙酰氨基酚急性中毒
Br Med J. 1970 Sep 5;3(5722):557-8. doi: 10.1136/bmj.3.5722.557.
6
Effect of activated charcoal on aspirin absorption in man. Part I.
Clin Pharmacol Ther. 1972 May-Jun;13(3):317-22. doi: 10.1002/cpt1972133317.
10
Some factors affecting the absorption of paracetamol.一些影响对乙酰氨基酚吸收的因素。
J Pharm Pharmacol. 1972 Aug;24(8):615-9. doi: 10.1111/j.2042-7158.1972.tb09072.x.

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