香豆素对患有各种高蛋白水肿的大鼠腿部蛋白质和聚乙烯吡咯烷酮清除率的影响。
The effect of coumarin on protein and PVP clearance from rat legs with various high protein oedemas.
作者信息
Piller N B, Casley-Smith J R
出版信息
Br J Exp Pathol. 1975 Oct;56(5):439-43.
Coumarin (a benzo-pyrone) has been shown to bring about the rapid removal of protein from normal or burnt tissues and from those with lymphoedema, with or without burning. This was particularly evident when the removal of protein was compared with that of a non-metabolizable control-PVP. The mode of action would seem to be by stimulation of proteolysis. The fragments of protein could then rapidly leave the tissues because of their small size, their high diffusion coefficients and a concentration gradient which was directed from the tissues to the blood. In this way excessive amounts of protein would be removed, thus releasing the oedema fluid. The removal of non-metabolizable PVP was reduced with normal and burnt legs, possibly of stimulated phagocytosis. In the presence of lymphoedema there was a more rapid removal of PVP with coumarin; this was possibly a consequence of the great reduction of intercapillary distances resulting from the removal of oedema fluid.
香豆素（一种苯并吡喃）已被证明能迅速从正常组织、烧伤组织以及有或无烧伤的淋巴水肿组织中去除蛋白质。与不可代谢的对照物聚乙烯吡咯烷酮（PVP）相比，蛋白质的去除情况时，这一点尤为明显。其作用方式似乎是通过刺激蛋白水解。由于蛋白质片段体积小、扩散系数高以及存在从组织指向血液的浓度梯度，它们随后能够迅速离开组织。通过这种方式，可以去除过量的蛋白质，从而释放出水肿液。正常腿部和烧伤腿部对不可代谢的PVP的清除减少，这可能是由于吞噬作用受到刺激。在存在淋巴水肿的情况下，香豆素能使PVP的清除更快；这可能是由于水肿液的去除导致毛细血管间距离大幅缩短的结果。
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