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Incorporation of Heterologous Deoxyribonucleic Acid into Mammalian Cells.异源脱氧核糖核酸在哺乳动物细胞中的整合。
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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THE IN VITRO DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. II. THE INFLUENCE OF SERUM ON GRANULE FORMATION, HYDROLASE PRODUCTION, AND PINOCYTOSIS.单核吞噬细胞的体外分化。II. 血清对颗粒形成、水解酶产生及胞饮作用的影响。
J Exp Med. 1965 May 1;121(5):835-48. doi: 10.1084/jem.121.5.835.
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THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY.单核吞噬细胞的分化。形态学、细胞化学与生物化学
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THE FATE OF DNA-CONTAINING PARTICLES PHAGOCYTIZED BY MAMMALIAN CELLS.被哺乳动物细胞吞噬的含DNA颗粒的命运
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CYTOCHEMICAL OBSERVATIONS ON THE RELATIONSHIP BETWEEN LYSOSOMES AND PHAGOSOMES IN KIDNEY AND LIVER BY COMBINED STAINING FOR ACID PHOSPHATASE AND INTRAVENOUSLY INJECTED HORSERADISH PEROXIDASE.通过酸性磷酸酶联合染色及静脉注射辣根过氧化物酶对肾脏和肝脏中溶酶体与吞噬体关系的细胞化学观察
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YOLK PROTEIN UPTAKE IN THE OOCYTE OF THE MOSQUITO AEDES AEGYPTI. L.埃及伊蚊卵母细胞中的卵黄蛋白摄取
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The fate of bacteria within phagocytic cells. I. The degradation of isotopically labeled bacteria by polymorphonuclear leucocytes and macrophages.吞噬细胞内细菌的命运。I. 多形核白细胞和巨噬细胞对同位素标记细菌的降解
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Studies on protein uptake by isolated tumor cells. II. Quantitative data on the adsorption and uptake of I-131-serum albumin by Ehrlich ascites tumor cells.离体肿瘤细胞摄取蛋白质的研究。II. 艾氏腹水瘤细胞对I-131-血清白蛋白的吸附和摄取的定量数据。
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巨噬细胞在体外对碘化人血清白蛋白的摄取与消化

The uptake and digestion of iodinated human serum albumin by macrophages in vitro.

作者信息

Ehrenreich B A, Cohn Z A

出版信息

J Exp Med. 1967 Nov 1;126(5):941-58. doi: 10.1084/jem.126.5.941.

DOI:10.1084/jem.126.5.941
PMID:6062005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138411/
Abstract

Mouse peritoneal macrophages take up I*-HSA from their medium during in vitro cultivation. Conditions which promote I*-HSA uptake are the same as those which stimulate formation of pinocytic vesicles. Autoradiography of cells pulsed with (125)I-HSA showed that intracellular isotope is localized in perinuclear granules, or secondary lysosomes. Following a pulse of (125)I-HSA, intracellular radioactivity decreases and the amount of TCA-soluble isotope in the medium increases correspondingly. About 50% of the intracellular isotope is lost in 5 hr. The release of isotope from pulsed cells is not inhibited by parafluorophenylalanine, 2,4-dinitrophenol or by a reduction of the serum concentration of the medium. However, the processing of ingested (125)I-HSA is reversibly inhibited by reduced temperature. The TCA-soluble radioactive material excreted by pulsed macrophages was identified as monoiodotyrosine.

摘要

在体外培养过程中，小鼠腹腔巨噬细胞从其培养基中摄取碘标记人血清白蛋白（I*-HSA）。促进I*-HSA摄取的条件与刺激胞饮小泡形成的条件相同。用碘-125标记人血清白蛋白（(125)I-HSA）脉冲处理细胞的放射自显影显示，细胞内的同位素定位于核周颗粒或次级溶酶体中。在用(125)I-HSA脉冲处理后，细胞内放射性降低，培养基中三氯乙酸可溶性同位素的量相应增加。约50%的细胞内同位素在5小时内丢失。来自脉冲处理细胞的同位素释放不受对氟苯丙氨酸、2,4-二硝基苯酚或培养基血清浓度降低的抑制。然而，摄入的(125)I-HSA的加工过程会被低温可逆性抑制。脉冲处理的巨噬细胞排泄的三氯乙酸可溶性放射性物质被鉴定为单碘酪氨酸。