Stulberg Daniel L, Penrod Marc A, Blatny Richard A
Utah Valley Family Practice Residency, Provo 84604, USA.
Am Fam Physician. 2002 Jul 1;66(1):119-24.
Family physicians frequently treat bacterial skin infections in the office and in the hospital. Common skin infections include cellulitis, erysipelas, impetigo, folliculitis, and furuncles and carbuncles. Cellulitis is an infection of the dermis and subcutaneous tissue that has poorly demarcated borders and is usually caused by Streptococcus or Staphylococcus species. Erysipelas is a superficial form of cellulitis with sharply demarcated borders and is caused almost exclusively by Streptococcus. Impetigo is also caused by Streptococcus or Staphylococcus and can lead to lifting of the stratum corneum resulting in the commonly seen bullous effect. Folliculitis is an inflammation of the hair follicles. When the infection is bacterial rather than mechanical in nature, it is most commonly caused by Staphylococcus. If the infection of the follicle is deeper and involves more follicles, it moves into the furuncle and carbuncle stages and usually requires incision and drainage. All of these infections are typically diagnosed by clinical presentation and treated empirically. If antibiotics are required, one that is active against gram-positive organisms such as penicillinase-resistant penicillins, cephalosporins, macrolides, or fluoroquinolones should be chosen. Children, patients who have diabetes, or patients who have immunodeficiencies are more susceptible to gram-negative infections and may require treatment with a second- or third-generation cephalosporin.
家庭医生常在诊所和医院治疗细菌性皮肤感染。常见的皮肤感染包括蜂窝织炎、丹毒、脓疱病、毛囊炎以及疖和痈。蜂窝织炎是真皮和皮下组织的感染,边界不清,通常由链球菌或葡萄球菌引起。丹毒是蜂窝织炎的一种浅表形式,边界清晰,几乎完全由链球菌引起。脓疱病也由链球菌或葡萄球菌引起,可导致角质层翘起,产生常见的大疱效应。毛囊炎是毛囊的炎症。当感染是细菌性而非机械性时,最常见的病因是葡萄球菌。如果毛囊感染更深且累及更多毛囊,就会发展为疖和痈阶段,通常需要切开引流。所有这些感染通常通过临床表现进行诊断并经验性治疗。如果需要使用抗生素,应选择对革兰氏阳性菌有效的药物,如耐青霉素酶的青霉素、头孢菌素、大环内酯类或氟喹诺酮类。儿童、糖尿病患者或免疫功能低下的患者更容易发生革兰氏阴性菌感染,可能需要使用第二代或第三代头孢菌素进行治疗。