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常见皮肤细菌感染的管理。

Management of common bacterial infections of the skin.

作者信息

Bernard Philippe

机构信息

Department of Dermatology, Robert Debré Hospital, Reims, France.

出版信息

Curr Opin Infect Dis. 2008 Apr;21(2):122-8. doi: 10.1097/QCO.0b013e3282f44c63.

Abstract

PURPOSE OF REVIEW

Bacterial skin infections commonly encountered in the community include impetigo, folliculitis/furunculosis, simple abscesses, erysipelas and other nonnecrotizing cellulitis. The review focuses on recent epidemiological, bacteriological and therapeutic advances.

RECENT FINDINGS

Impetigo and erysipelas occur in about 20 and 1 person/1000/year, respectively. Main risk factors for erysipelas are toe-web intertrigo and lymphedema. The true incidence of furunculosis is unknown, whereas outbreaks in small communities are reported worldwide. Staphylococcus aureus is the predominant pathogen for impetigo and furunculosis, and methicillin-resistant strains play a growing role in both diseases. Erysipelas are mainly caused by streptococci, whereas local complications (i.e. abscesses or blisters) may be due to staphylococci, including methicillin-resistant strains in involved geographic areas. Recent trends for treating impetigo and furunculosis predate community-acquired methicillin-resistant S. aureus. For outbreaks of furunculosis, stringent decolonization measures are showing promise, whereas there is no validated therapeutic regimen for chronic furunculosis. Current trends for erysipelas involve ambulatory treatments and reduced duration of antibiotics.

SUMMARY

Despite better epidemiological or bacteriological knowledge of common bacterial skin infections, the exact role of methicillin-resistant staphylococci needs regular surveys in involved geographic areas. Antibiotic treatment must be active on staphylococci and, to a lesser degree, on streptococci.

摘要

综述目的

社区中常见的细菌性皮肤感染包括脓疱病、毛囊炎/疖病、单纯性脓肿、丹毒和其他非坏死性蜂窝织炎。本综述重点关注近期的流行病学、细菌学和治疗进展。

最新发现

脓疱病和丹毒的发病率分别约为每年20例/1000人和1例/1000人。丹毒的主要危险因素是趾间擦烂和淋巴水肿。疖病的真实发病率尚不清楚,而世界各地均有小社区爆发的报道。金黄色葡萄球菌是脓疱病和疖病的主要病原体,耐甲氧西林菌株在这两种疾病中发挥着越来越重要的作用。丹毒主要由链球菌引起,而局部并发症(如脓肿或水疱)可能由葡萄球菌引起,包括在相关地理区域的耐甲氧西林菌株。治疗脓疱病和疖病的最新趋势早于社区获得性耐甲氧西林金黄色葡萄球菌。对于疖病的爆发,严格的去定植措施显示出前景,而慢性疖病尚无经过验证的治疗方案。丹毒目前的治疗趋势包括门诊治疗和缩短抗生素使用时间。

总结

尽管对常见细菌性皮肤感染有了更好的流行病学或细菌学认识,但耐甲氧西林葡萄球菌的确切作用仍需在相关地理区域定期进行调查。抗生素治疗必须对葡萄球菌有效,对链球菌的有效性次之。

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