Saxena R S, Gupta B, Lata S
Department of Pharmacology, L.L.R.M. Medical College, Meerut 250 004, India.
J Ethnopharmacol. 2002 Aug;81(3):321-5. doi: 10.1016/s0378-8741(02)00088-0.
The decoction of the leaves of Nyctanthes arbor tristis Linn. (Harsingar) is widely used in Ayurvedic system of medicine for the treatment of sciatica, arthritis, fevers, various painful conditions and as laxative. In the present investigation, the water soluble portion of the alcoholic extract of the leaves was screened for some CNS activities (viz. hypnotic, tranquilizing, local anaesthetic, hypothermic, anticonvulsant), antihistaminic and purgative activities. The extract produced general depression of spontaneous motor activity, significantly increased pentobarbitone sleeping time though it had no effect on righting reflex. Furthermore higher doses of the extract abolished CAR without affecting motor coordination. Moreover the extract exhibited hypothermic effect and protected guinea pigs from histamine aerosol. These activities are common to major tranquilizers and support the usage of the plant by Ayurvedic physicians in aforementioned conditions. In addition significant purgative activity was also exhibited by the extract.
夜香树（Harsingar）叶子的煎剂在阿育吠陀医学体系中被广泛用于治疗坐骨神经痛、关节炎、发烧、各种疼痛病症以及用作泻药。在本研究中，对叶子乙醇提取物的水溶性部分进行了一些中枢神经系统活性（即催眠、镇静、局部麻醉、体温降低、抗惊厥）、抗组胺和泻药活性的筛选。该提取物使自发运动活动普遍受到抑制，显著延长戊巴比妥睡眠时间，尽管对翻正反射没有影响。此外，较高剂量的提取物消除了条件性回避反应，而不影响运动协调性。而且该提取物表现出体温降低作用，并保护豚鼠免受组胺气雾剂的影响。这些活性是主要镇静剂所共有的，支持阿育吠陀医生在上述病症中使用该植物。此外，该提取物还表现出显著的泻药活性。
