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人胎儿心脏中去甲肾上腺素的合成

Noradrenaline synthesis in human fetal heart.

作者信息

Gennser G, Von Studnitz W

出版信息

Experientia. 1975 Dec 15;31(12):1422-4. doi: 10.1007/BF01923223.

DOI:10.1007/BF01923223
PMID:1213060
Abstract

The capacity of noradrenaline synthesis was investigated in 6 isolated human fetal hearts (13-23 gestational week). The mean rate of transforming perfused labelled tyrosine to noradrenaline in atrial, ventricular, and mediastinal tissue was 0.175, 0.168, and 0.108 mug/g tissue/h, respectively.

摘要

在6个离体人胎儿心脏（妊娠13 - 23周）中研究了去甲肾上腺素合成能力。心房、心室和纵隔组织中灌注的标记酪氨酸转化为去甲肾上腺素的平均速率分别为0.175、0.168和0.108微克/克组织/小时。

相似文献

1
Noradrenaline synthesis in human fetal heart.人胎儿心脏中去甲肾上腺素的合成
Experientia. 1975 Dec 15;31(12):1422-4. doi: 10.1007/BF01923223.
2
The effect of nerve stimulation on the synthesis of 3H-noradrenaline from 3H-tyrosine in the isolated blood-perfused cat spleen.神经刺激对离体血液灌流猫脾脏中从3H-酪氨酸合成3H-去甲肾上腺素的影响。
J Physiol. 1969 Jan;200(1):59P-60P.
3
Tyrosine availability and brain noradrenaline synthesis in the fetus: control by maternal tyrosine ingestion.
Brain Res. 1988 Aug 9;457(2):330-7. doi: 10.1016/0006-8993(88)90703-2.
4
Responsiveness to glucagon in fetal hearts. Species variability and apparent disparities between changes in beating, adenylate cyclase activation, and cyclic AMP concentration.胎儿心脏对胰高血糖素的反应性。物种差异以及心跳变化、腺苷酸环化酶激活和环磷酸腺苷浓度变化之间明显的差异。
J Clin Invest. 1976 Mar;57(3):551-8. doi: 10.1172/JCI108310.
5
The synthesis of noradrenaline by isolated guinea-pig atria.豚鼠离体心房去甲肾上腺素的合成
Biochem J. 1966 Jun;99(3):538-45. doi: 10.1042/bj0990538.
6
Development of noradrealine uptake in the human foetal heart.去甲肾上腺素摄取在人胎儿心脏中的发育情况。
Experientia. 1977 Feb 15;33(2):251-3. doi: 10.1007/BF02124094.
7
Maturation of responsiveness to cardioactive drugs. Differential effects of acetylcholine, norepinephrine, theophylline, tyramine, glucagon, and dibutyryl cyclic AMP on atrial rate in hearts of fetal mice.对心血管活性药物反应性的成熟。乙酰胆碱、去甲肾上腺素、茶碱、酪胺、胰高血糖素和二丁酰环磷酸腺苷对胎鼠心脏心房率的不同影响。
J Clin Invest. 1973 Sep;52(9):2250-8. doi: 10.1172/JCI107411.
8
Functional development of adrenergic uptake mechanisms in the human fetal heart.人类胎儿心脏中肾上腺素能摄取机制的功能发育
Biol Neonate. 1983;43(3-4):158-63. doi: 10.1159/000241623.
9
[The action of heart factor H1 on the synthesis and uptake of dopamine and noradrenaline in the rat heart].[心脏因子H1对大鼠心脏中多巴胺和去甲肾上腺素合成及摄取的作用]
Fiziol Zh SSSR Im I M Sechenova. 1988 Jul;74(7):948-52.
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Acceleration of noradrenaline biosynthesis in the guinea-pig vas deferens by potassium.钾离子对豚鼠输精管去甲肾上腺素生物合成的加速作用。
Br J Pharmacol. 1970 Dec;40(4):702-20. doi: 10.1111/j.1476-5381.1970.tb10648.x.

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Developmental expression of catecholamine system in the human placenta and rat fetoplacental unit.人胎盘和大鼠胎胎盘单位儿茶酚胺系统的发育表达。
Sci Rep. 2024 Mar 23;14(1):6948. doi: 10.1038/s41598-024-57481-5.
2
Development of the peptidergic innervation of human heart.人类心脏肽能神经支配的发育
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Autonomic responses and neurohumoral control in the human early antenatal heart.人类早期产前心脏的自主反应和神经体液控制。

本文引用的文献

1
ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART.灌注豚鼠心脏中去甲肾上腺素生物合成限速步骤的阐明
J Pharmacol Exp Ther. 1965 Apr;148:1-8.
2
BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.酪氨酸羟化酶抑制剂α-甲基酪氨酸对内源性去甲肾上腺素合成的阻断作用
J Pharmacol Exp Ther. 1965 Jan;147:86-95.
3
A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.一项关于影响用于儿茶酚胺分析的氧化铝 - 三羟基吲哚法的因素的研究。
Basic Res Cardiol. 1988 Jan-Feb;83(1):2-9. doi: 10.1007/BF01907099.
4
Anaesthesia for the neonate.
Can J Anaesth. 1991 May;38(4 Pt 2):R105-25. doi: 10.1007/BF03008439.
J Pharmacol Exp Ther. 1962 Dec;138:360-75.
4
Norepinephrine synthesis from tyrosine-C-14 in isolated perfused guinea pig heart.在离体灌注豚鼠心脏中由酪氨酸-C-14合成去甲肾上腺素
Science. 1963 Mar 29;139(3561):1299-301. doi: 10.1126/science.139.3561.1299.
5
A method for the fluorimetric determination of adrenaline and noradrenaline in tissues.一种用于荧光测定组织中肾上腺素和去甲肾上腺素的方法。
Acta Physiol Scand. 1958 Dec 15;44(3-4):273-92. doi: 10.1111/j.1748-1716.1958.tb01627.x.
6
Field stimulation as a means of effecting the graded release of autonomic transmitters in isolated heart muscle.场刺激作为一种在离体心肌中实现自主递质分级释放的手段。
J Pharmacol Exp Ther. 1966 Feb;151(2):221-35.
7
Anoxia-induced release of noradrenaline from the isolated perfused heart.缺氧诱导去甲肾上腺素从离体灌注心脏释放。
Nature. 1965 Jul 3;207(992):88-9. doi: 10.1038/207088a0.
8
Adrenergic support of cardiac function during hypoxia in the newborn lamb.新生羔羊缺氧时心脏功能的肾上腺素能支持
Am J Physiol. 1969 Sep;217(3):728-35. doi: 10.1152/ajplegacy.1969.217.3.728.
9
Adrenergic and cholinesterase-containing neurons of the heart.心脏中含肾上腺素能和胆碱酯酶的神经元。
Histochemie. 1968;16(3):197-205. doi: 10.1007/BF00307848.
10
Noradrenaline uptake mechanisms in the mouse atrium. A biochemical and histochemical study.小鼠心房中的去甲肾上腺素摄取机制。一项生化与组织化学研究。
Acta Physiol Scand Suppl. 1970;341:1-66.