在离体灌注豚鼠心脏中由酪氨酸-C-14合成去甲肾上腺素
Norepinephrine synthesis from tyrosine-C-14 in isolated perfused guinea pig heart.
作者信息
SPECTOR S, SJOERDSMA A, ZALTZMAN-NIRENBERG P, LEVITT M, UDENFRIEND S
出版信息
Science. 1963 Mar 29;139(3561):1299-301. doi: 10.1126/science.139.3561.1299.
Abstract
The isolated, perfused guinea pig heart contains all the catalysts required to form norepinephrine from the dietary precursor, tyrosine. The conversion of tyrosine-C(14) to norepinephrine in the perfused heart occurred at a rate comparable to that estimated for this conversion in vivo. To account for the maintenance of norepinephrine stores in the normal heart, it is not necessary to postulate that the hormone is extracted from the blood.
摘要
分离的灌注豚鼠心脏含有从膳食前体酪氨酸形成去甲肾上腺素所需的所有催化剂。在灌注心脏中，酪氨酸-C(14) 转化为去甲肾上腺素的速率与体内该转化的估计速率相当。为了解释正常心脏中去甲肾上腺素储备的维持，无需假定该激素是从血液中提取的。
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