Kantariia V A, Lebedev A A
Farmakol Toksikol. 1975 Jul-Aug;38(4):430-3.
In acute experiments on rats the xanthine diuretic euphylline did not block the short-circuited current in the proximal tubule, nor did it lower the transtubular potential and the transepithelial resistance of the nephron wall. The diuretic speeded up significantly the passage of the tubular fluid along the proximal region of the nephron and Henle's loop. The dihydroergotoxin and inderal blocking of adrenoreceptors did not produce any influence on the renal effects of the xanthine agent. Reserpine totally blocked the diuretic and saluretic effects of euphylline, whereas other sympatholytics, such as alpha-methyl-dofa, anthabus and hemedin, did not modify the action of the diuretic.
在对大鼠进行的急性实验中，黄嘌呤利尿剂氨茶碱并未阻断近端小管的短路电流，也未降低肾小管电位及肾单位壁的跨上皮电阻。该利尿剂显著加快了肾小管液沿肾单位近端区域及亨氏袢的通过速度。二氢麦角毒素及心得安对肾上腺素能受体的阻断未对黄嘌呤类药物的肾脏效应产生任何影响。利血平完全阻断了氨茶碱的利尿和促尿钠排泄作用，而其他交感神经阻滞剂，如α-甲基多巴、安他布司和海米那，并未改变该利尿剂的作用。
