Kantariia V A
Farmakol Toksikol. 1977 May-Jun;40(3):331-3.
Reserpine and galoperidol are shown to exercise blocking effect with regard to the diuretic and saluretic action of the xanthine-euphylline. Galoperiod prevented an accretion of the total renal blood flow induced by euphylline. Preliminary introduction to rats of alpha-methyl-DOPA and 1-DOPA abolished the blocking action of reserpine on the renal effects of euphylline. The renal influence of euphylline is mediated through dopamine-ergic structures, which are non-identical to adrenostructures. Dopamine is not merely a precursor of norepinephrine and epinephrine, but performs functions of its own in the organism.
利血平和氟哌啶醇对黄嘌呤-优菲林的利尿和促尿钠排泄作用具有阻断效应。氟哌啶醇可阻止优菲林诱导的肾总血流量增加。预先给大鼠注射α-甲基多巴和左旋多巴可消除利血平对优菲林肾脏效应的阻断作用。优菲林的肾脏影响是通过多巴胺能结构介导的，这些结构与肾上腺结构不同。多巴胺不仅是去甲肾上腺素和肾上腺素的前体，而且在机体中发挥自身的功能。
