分子克隆的高传代鸡贫血病毒分离株所表现出的致弱分子基础。
Molecular basis of the attenuation exhibited by molecularly cloned highly passaged chicken anemia virus isolates.
作者信息
Todd Daniel, Scott Alistair N J, Ball Neris W, Borghmans Borghert J, Adair Brian M
机构信息
Department of Agriculture and Rural Development for Northern Ireland, Veterinary Sciences Division, the Queen's University of Belfast, Stormont, United Kingdom.
出版信息
J Virol. 2002 Aug;76(16):8472-4. doi: 10.1128/jvi.76.16.8472-8474.2002.
Abstract
Chimeric virus experiments indicated that the pathogenicity and monoclonal antibody reactivity differences between two molecularly cloned, highly passaged chicken anemia virus isolates could be attributed to the VP1 amino acid change at residue 89. The introduction of this change into a pathogenic cloned low-passage isolate was not sufficient to cause attenuation.
摘要
嵌合病毒实验表明，两种分子克隆的、经过高度传代的鸡贫血病毒分离株之间的致病性和单克隆抗体反应性差异可归因于第89位氨基酸处的VP1氨基酸变化。将此变化引入致病的克隆低传代分离株中不足以导致病毒减毒。
相似文献
1
Molecular basis of the attenuation exhibited by molecularly cloned highly passaged chicken anemia virus isolates.
J Virol. 2002 Aug;76(16):8472-4. doi: 10.1128/jvi.76.16.8472-8474.2002.
2
Antigenicity and pathogenicity characteristics of molecularly cloned chicken anaemia virus isolates obtained after multiple cell culture passages.
Arch Virol. 1999;144(10):1961-75. doi: 10.1007/s007050050718.
3
Investigation of the attenuation exhibited by a molecularly cloned chicken anemia virus isolate by utilizing a chimeric virus approach.
J Virol. 1997 Nov;71(11):8362-7. doi: 10.1128/JVI.71.11.8362-8367.1997.
4
Characterisation of a chicken anaemia virus variant population that resists neutralisation with a group-specific monoclonal antibody.
Arch Virol. 2001;146(4):713-28. doi: 10.1007/s007050170141.
5
Immunopathologic investigations with an attenuated chicken anemia virus in day-old chickens.
Avian Dis. 2003 Oct-Dec;47(4):1339-45. doi: 10.1637/7005.
6
Immunopathogenesis of attenuated strain of chicken infectious anemia virus in one-day-old specific-pathogen-free chicks.
Egypt J Immunol. 2003;10(1):89-102.
7
Identification of a genetic determinant of pathogenicity in chicken anaemia virus.
J Gen Virol. 2001 May;82(Pt 5):1233-1238. doi: 10.1099/0022-1317-82-5-1233.
8
Development of a DNA vaccine against chicken anemia virus by using a bicistronic vector expressing VP1 and VP2 proteins of CAV.
Comp Immunol Microbiol Infect Dis. 2011 May;34(3):227-36. doi: 10.1016/j.cimid.2010.11.006. Epub 2010 Dec 13.
9
Investigation of the unstable attenuation exhibited by a chicken anaemia virus isolate.
Avian Pathol. 2003 Aug;32(4):375-82. doi: 10.1080/037945031000121121.
10
Biological characterization of Nigerian chicken anaemia virus isolates.
Afr J Med Med Sci. 2010 Dec;39 Suppl:21-6.
引用本文的文献
1
Genetic heterogeneity of chicken anemia virus isolated in selected Egyptian provinces as a preliminary investigation.
Front Vet Sci. 2024 May 22;11:1362219. doi: 10.3389/fvets.2024.1362219. eCollection 2024.
2
Genetic characterization of chicken infectious anaemia viruses isolated in Korea and their pathogenicity in chicks.
Front Cell Infect Microbiol. 2024 Feb 13;14:1333596. doi: 10.3389/fcimb.2024.1333596. eCollection 2024.
3
Molecular Characteristics of Chicken Infectious Anemia Virus in Central and Eastern China from 2020 to 2022.
Animals (Basel). 2023 Aug 25;13(17):2709. doi: 10.3390/ani13172709.
4
First detection and genetic characterization of chicken infectious anemia virus in the Mekong Delta, Vietnam.
Open Vet J. 2023 Jun;13(6):690-696. doi: 10.5455/OVJ.2023.v13.i6.3. Epub 2023 Jun 4.
5
Genetic diversity, distribution, and evolution of chicken anemia virus: A comparative genomic and phylogenetic analysis.
Front Microbiol. 2023 Mar 9;14:1145225. doi: 10.3389/fmicb.2023.1145225. eCollection 2023.
6
Molecular characterization of chicken anemia virus in Guangxi Province, southern China, from 2018 to 2020.
J Vet Sci. 2022 Sep;23(5):e63. doi: 10.4142/jvs.22023. Epub 2022 Jul 8.
7
Genomic Characterization of CIAV Detected in Contaminated Attenuated NDV Vaccine: Epidemiological Evidence of Source and Vertical Transmission From SPF Chicken Embryos in China.
Front Vet Sci. 2022 Jul 6;9:930887. doi: 10.3389/fvets.2022.930887. eCollection 2022.
8
Long read sequencing revealed proventricular virome of broiler chicken with transmission viral proventriculitis.
BMC Vet Res. 2022 Jun 29;18(1):253. doi: 10.1186/s12917-022-03339-9.
9
Genomic Sequence and Pathogenicity of the Chicken Anemia Virus Isolated From Chicken in Yunnan Province, China.
Front Vet Sci. 2022 May 18;9:860134. doi: 10.3389/fvets.2022.860134. eCollection 2022.
10
Genomic Characterization of Chicken Anemia Virus in Broilers in Shandong Province, China, 2020-2021.
Front Vet Sci. 2022 Mar 17;9:816860. doi: 10.3389/fvets.2022.816860. eCollection 2022.
本文引用的文献
1
Chicken anaemia agent: a review.
Avian Pathol. 1991 Jun;20(2):187-203. doi: 10.1080/03079459108418756.
2
Characterisation of a chicken anaemia virus variant population that resists neutralisation with a group-specific monoclonal antibody.
Arch Virol. 2001;146(4):713-28. doi: 10.1007/s007050170141.
3
Identification of a genetic determinant of pathogenicity in chicken anaemia virus.
J Gen Virol. 2001 May;82(Pt 5):1233-1238. doi: 10.1099/0022-1317-82-5-1233.
4
Virus taxonomy at the XIth International Congress of Virology, Sydney, Australia, 1999.
Arch Virol. 1999;144(10):2065-70. doi: 10.1007/s007050050728.
5
Antigenicity and pathogenicity characteristics of molecularly cloned chicken anaemia virus isolates obtained after multiple cell culture passages.
Arch Virol. 1999;144(10):1961-75. doi: 10.1007/s007050050718.
6
PCR-ligation-PCR mutagenesis: a protocol for creating gene fusions and mutations.
Biotechniques. 1995 May;18(5):746-50.
7
Chicken anemia agent in the United States: isolation of the virus and detection of antibody in broiler breeder flocks.
Avian Dis. 1989 Oct-Dec;33(4):691-4.
8
Purification and biochemical characterization of chicken anaemia agent.
J Gen Virol. 1990 Apr;71 ( Pt 4):819-23. doi: 10.1099/0022-1317-71-4-819.
9
Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle.
J Virol. 1991 Jun;65(6):3131-9. doi: 10.1128/JVI.65.6.3131-3139.1991.
10
Characterization of viral DNAs from cells infected with chicken anaemia agent: sequence analysis of the cloned replicative form and transfection capabilities of cloned genome fragments.
Arch Virol. 1992;124(3-4):301-19. doi: 10.1007/BF01309811.
Zotero 插件