Nagata Taeko, Suzuki Takashi, Ohta Yuko, Flajnik Martin F, Kasahara Masanori
Department of Biosystems Science, School of Advanced Sciences, The Graduate University for Advanced Studies, Sokendai, Shonan Village, Hayama 240-0193, Japan.
Immunogenetics. 2002 Jul;54(4):286-91. doi: 10.1007/s00251-002-0469-1. Epub 2002 Jun 19.
CD45, originally known as the leukocyte common antigen, is a prototypical transmembrane protein tyrosine phosphatase that plays a critical role in signal transduction through T-cell and B-cell receptors, as well as in T-cell and B-cell development. In the present study, we show that the Pacific hagfish, widely believed to lack the adaptive immune system, has CD45. The presence of CD45 in jawless fish is consistent with the recent discovery that CD45 also plays a crucial role in innate immunity via the regulation of signaling through type I and type II cytokine receptors. It is likely that CD45 was recruited to activate lymphocytes through antigen receptors encoded by rearranging genes in jawed vertebrates.
CD45最初被称为白细胞共同抗原，是一种典型的跨膜蛋白酪氨酸磷酸酶，在通过T细胞和B细胞受体的信号转导以及T细胞和B细胞发育中起关键作用。在本研究中，我们表明，普遍认为缺乏适应性免疫系统的太平洋盲鳗具有CD45。无颌鱼类中存在CD45与最近的一项发现一致，即CD45通过调节I型和II型细胞因子受体的信号传导，在先天免疫中也起着关键作用。很可能CD45被招募来通过颌类脊椎动物中重排基因编码的抗原受体激活淋巴细胞。
