Holmes Nick
Division of Immunology, Department of Pathology, Cambridge University, UK.
Immunology. 2006 Feb;117(2):145-55. doi: 10.1111/j.1365-2567.2005.02265.x.
CD45 has been recognized as an important player in regulating signalling in lymphocytes. However, compared with tyrosine kinases, phosphatases are still poorly understood in terms of the details of their specificity and regulation. Here, the recent progress in understanding the biology of the first recognized receptor tyrosine phosphatase, CD45, is reviewed.
CD45已被公认为调节淋巴细胞信号传导的重要因子。然而,与酪氨酸激酶相比,磷酸酶在其特异性和调节细节方面仍知之甚少。本文综述了对首个被识别的受体酪氨酸磷酸酶CD45生物学特性理解的最新进展。