中国北方细菌性眼病的病因分析（1989 - 1998年）

Etiological analysis on bacterial ocular disease in northern China (1989-1998).

作者信息

Sun Wang, Wang Zhiqun, Chen Lin, Luo Shiyun, Jin Xiuying, Zhang Wenhua

机构信息

Department of Ophthalmologic Microbiology, Beijing Institute of Ophthalmology, China.

出版信息

Chin Med J (Engl). 2002 Jun;115(6):933-5.

PMID:12136809

Abstract

OBJECTIVE

To review the distribution and trends of bacterial culture specimens in Beijing Institute of Ophthalmology.

METHODS

A retrospective analysis of the bacterial culture-positive rate, the distribution of gram' s stain, and the distribution and change of isolates was performed on 4705 specimens during a 10-year period (1989- 1998).

RESULTS

Positive cultures numbered 1339 of the 4705 specimens, with a positive rate of 28.6%. Gram-positive cocci constituted 55.6% of the total isolates, followed by gram-positive bacilli 13.1% . Gram-negative cocci accounted for 2.8%, and gram-negative bacilli 28.5% . In the positive bacteria cultures, coagulase-negative Staphylococcus (mainly Staphylococcous epidermidis) was the most common isolate (25.3%), and followed by Pseudomonas 18.8%, Micrococcus 11.7%, Cotynbaccterium 10.1%, and Staphylococcus aureus 8.2% . During the 10-year period, the overall frequency of gram-positive cocci appeared to increase with time while the frequency of gram-negative bacilli decreased.

CONCLUSIONS

Gram-positive cocci and gram-negative bacilli are still the predominant pathogens of ocular infection in northern China. The frequency of the former increases annually whereas that of the latter decreases. It is important to comprehend the distribution and trends of ocular pathogenic bacteria for the diagnosis, prevention and treatment of bacterial infectious ocular disease.

摘要

目的

回顾北京同仁眼科中心细菌培养标本的分布及变化趋势。

方法

对1989 - 1998年10年间4705份标本的细菌培养阳性率、革兰染色分布及菌株的分布与变化进行回顾性分析。

结果

4705份标本中培养阳性者1339份，阳性率为28.6%。革兰阳性球菌占分离菌总数的55.6%，其次为革兰阳性杆菌占13.1%，革兰阴性球菌占2.8%，革兰阴性杆菌占28.5%。在阳性菌培养中，凝固酶阴性葡萄球菌（主要是表皮葡萄球菌）最为常见（25.3%），其次为铜绿假单胞菌18.8%、微球菌11.7%、棒状杆菌10.1%、金黄色葡萄球菌8.2%。10年间，革兰阳性球菌的总体构成比随时间呈上升趋势，而革兰阴性杆菌呈下降趋势。