Mangesi L, Hofmeyr G J
Effective Care Research Group, Frere Maternity Hospital, Private Bag X9047, East London, South Africa, 5200.
Cochrane Database Syst Rev. 2002;2002(3):CD003516. doi: 10.1002/14651858.CD003516.
It is customary for fluids and/or food to be withheld for a period of time after abdominal operations. After caesarean section, practices vary considerably. These discrepancies raise concern as to the bases of different practices.
To assess the effect of early versus delayed introduction of fluids and/or food after caesarean section.
We searched the Cochrane Pregnancy and Childbirth Group trials register (January 2002) and the Cochrane Controlled Trials Register (The Cochrane Library, Issue 4, 2001).
Clinical trials with random allocation comparing early versus delayed oral fluids and/or food after caesarean section were considered. The participants were women within the first 24 hours after caesarean section. The criteria for 'early' feeding were as defined by the individual trial authors - usually within six to eight hours of surgery.
Trials considered were evaluated for methodological quality and appropriateness for inclusion. For dichotomous data, relative risks and 95% confidence intervals were calculated. Continuous data were compared using weighted mean difference and 95% confidence interval. Sub-group analyses were performed for general anaesthesia, regional analgesia and where anaesthesia was mixed or undefined.
Of 12 studies considered, six were included in this review. Four were excluded and two are pending further information. The methodological quality of the studies was variable. Only one to three studies contributed usable data to each outcome. Three studies were limited to surgery under regional analgesia, while three included both regional analgesia and general anaesthesia. Early oral fluids or food were associated with: reduced time to first food intake (one study, 118 women; the intervention was a slush diet and food was introduced according to clinical parameters; weighted mean difference -7.20 hours, 95% confidence interval -13.26 to -1.14); reduced time to return of bowel sounds (one study, 118 women; -4.30 hours, -6.78 to -1.82); reduced postoperative hospital stay following surgery under regional analgesia (two studies, 220 women; -0.75 days, -1.37 to -0.12 - random effects model); and a trend to reduced abdominal distension (three studies, 369 women; relative risk 0.78, 95% confidence interval 0.55 to 1.11). No significant differences were identified with respect to nausea, vomiting, time to bowel action/ passing flatus, paralytic ileus and number of analgesic doses.
REVIEWER'S CONCLUSIONS: There was no evidence from the limited randomised trials reviewed, to justify a policy of withholding oral fluids after uncomplicated caesarean section. Further research is justified.
腹部手术后通常会在一段时间内禁食禁水。剖宫产术后的做法差异很大。这些差异引发了人们对不同做法依据的关注。
评估剖宫产术后早期与延迟摄入液体和/或食物的效果。
我们检索了Cochrane妊娠与分娩组试验注册库(2002年1月)和Cochrane对照试验注册库(《Cochrane图书馆》,2001年第4期)。
考虑采用随机分配的临床试验,比较剖宫产术后早期与延迟口服液体和/或食物的情况。参与者为剖宫产术后24小时内的女性。“早期”喂养的标准由各试验作者定义,通常在术后6至8小时内。
对纳入的试验进行方法学质量评估和纳入的适宜性评估。对于二分数据,计算相对风险和95%置信区间。使用加权平均差和95%置信区间比较连续数据。对全身麻醉、区域镇痛以及麻醉方式混合或不明确的情况进行亚组分析。
在12项纳入考虑的研究中,6项被纳入本综述。4项被排除,2项有待进一步信息。研究的方法学质量参差不齐。每个结局仅有1至三项研究提供了可用数据。3项研究仅限于区域镇痛下的手术,而3项研究同时包括区域镇痛和全身麻醉。早期口服液体或食物与以下情况相关:首次进食时间缩短(一项研究,118名女性;干预措施为半流质饮食,根据临床参数引入食物;加权平均差-7.20小时,95%置信区间-13.26至-1.14);肠鸣音恢复时间缩短(一项研究,118名女性;-4.30小时,-6.78至-1.82);区域镇痛下手术后住院时间缩短(两项研究,220名女性;-0.75天,-1.37至-0.12——随机效应模型);以及腹胀减轻的趋势(三项研究,369名女性;相对风险0.78,95%置信区间0.55至1.11)。在恶心、呕吐、排便/排气时间、麻痹性肠梗阻和镇痛剂使用剂量方面未发现显著差异。
在所综述的有限随机试验中,没有证据支持在无并发症的剖宫产术后采取禁食禁水的政策。有必要进行进一步研究。