Korsching Sigrun
Institut für Genetik, Universität zu Köln, 50674, Köln, Germany.
Curr Opin Neurobiol. 2002 Aug;12(4):387-92. doi: 10.1016/s0959-4388(02)00348-3.
The understanding of neuronal processing of olfactory stimuli has been furthered by genetic studies and specialized imaging of particular neuronal populations. Selective optical imaging of odor-induced presynaptic and postsynaptic glomerular activity in the olfactory bulb/antennal lobe has visualized odorant-responsive receptor repertoires and shown a more confined odor image at the level of projection neurons compared to their olfactory receptor neuron input. Genetic tracing of projection neurons connected to particular glomeruli has revealed a somewhat dispersed spatial map of termination areas for these neurons both in insects and in vertebrates. Modifications of the glomerular odor map have resulted in altered percepts of the corresponding odors.
对嗅觉刺激的神经元处理过程的理解，已通过遗传学研究和对特定神经元群体的专门成像得到了推进。对嗅球/触角叶中气味诱导的突触前和突触后小球活动进行选择性光学成像，已使气味反应性受体库可视化，并显示出与嗅觉受体神经元输入相比，投射神经元水平上的气味图像更为局限。对连接到特定小球的投射神经元进行基因追踪，已揭示出这些神经元在昆虫和脊椎动物中终止区域的空间图谱都有些分散。小球气味图谱的改变已导致对相应气味的感知发生变化。
