Ramsay D J, Reid I A
J Physiol. 1975 Dec;253(2):517-25. doi: 10.1113/jphysiol.1975.sp011204.
Measurements of water intake were made on a population of trained conscious dogs of both sexes prepared with chronic third ventricle cannulae. 2. Injection of 100 ng angiotensin II into the third ventricle lead to a prompt stimulation of drinking, the mean water intake over a 5 min period being 503 +/- 89 ml. (n=6) compared with controls. This dipsogenic effect of angiotensin II was abolished by prior central administration of 10 mug saralasin acetate or 100 ng atropine. 3. Injection of 1 mug carbachol into the third ventricle produced a small, variable increase in drinking. 4. Injection of 0-2 ml. 5% NaCl into the third ventricle stimulated drinking, a response that was not affected by prior administration of 10 mug saralasin acetate or 100 ng atropine. 5. Following a 24 hr period of water deprivation there was an increase in plasma osmolality and plasma-renin activity. The drinking following this period of water deprivation was not affected by prior control administration of either 10 mug saralasin acetate or 100 ng atropine. 6. In two acute dogs, intracarotid infusion of 125I angiotensin II was not followed by significant appearance of radioactivity in the third ventricle or cisterna magna c.s.f. 7. The relevance of these results to the control of water intake is discussed.
对一群通过慢性第三脑室插管制备的、经过训练的雌雄清醒犬进行了水摄入量的测量。2. 向第三脑室内注射100 ng血管紧张素II可迅速刺激饮水，与对照组相比，5分钟内的平均水摄入量为503±89毫升（n = 6）。血管紧张素II的这种致渴作用可被预先经中枢给予10 μg醋丁洛尔或100 ng阿托品消除。3. 向第三脑室内注射1 μg卡巴胆碱可使饮水量有小幅度的、变化不定的增加。4. 向第三脑室内注射0.2毫升5%氯化钠可刺激饮水，该反应不受预先给予10 μg醋丁洛尔或100 ng阿托品的影响。5. 在24小时禁水期后，血浆渗透压和血浆肾素活性增加。这段禁水期后的饮水不受预先给予10 μg醋丁洛尔或100 ng阿托品的影响。6. 在两只急性犬中，颈内动脉输注125I血管紧张素II后，第三脑室或枕大池脑脊液中未出现明显的放射性。7. 讨论了这些结果与水摄入量控制的相关性。
