大肠杆菌的NorR蛋白响应活性氮物种激活黄素氧还蛋白基因norV的表达。
The NorR protein of Escherichia coli activates expression of the flavorubredoxin gene norV in response to reactive nitrogen species.
作者信息
Hutchings Matthew I, Mandhana Neeraj, Spiro Stephen
机构信息
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
出版信息
J Bacteriol. 2002 Aug;184(16):4640-3. doi: 10.1128/JB.184.16.4640-4643.2002.
Abstract
The Escherichia coli norVW genes encode a flavorubredoxin and NADH:(flavo)rubredoxin reductase, respectively, which are involved in nitric oxide detoxification under anaerobic growth conditions. Here it is shown that the norVW genes also have a role in protection against reactive nitrogen intermediates generated from nitroprusside. Transcription from the norV promoter is activated by the presence of nitroprusside in the growth medium; activation requires the product of a divergently transcribed regulatory gene, norR.
摘要
大肠杆菌的norVW基因分别编码一种黄素铁氧化还原蛋白和NADH：（黄素）铁氧化还原蛋白还原酶，它们在厌氧生长条件下参与一氧化氮解毒。本文表明，norVW基因在抵御由硝普钠产生的活性氮中间体方面也发挥作用。生长培养基中硝普钠的存在可激活norV启动子的转录；这种激活需要一个反向转录的调控基因norR的产物。
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The NorR protein of Escherichia coli activates expression of the flavorubredoxin gene norV in response to reactive nitrogen species.大肠杆菌的NorR蛋白响应活性氮物种激活黄素氧还蛋白基因norV的表达。
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本文引用的文献
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