Latorre R, Alvarez O, Ehrenstein G, Espinoza M, Reyes J
J Membr Biol. 1975 Dec 4;25(1-2):163-81. doi: 10.1007/BF01868573.
The electrical responses of individual hemocyanain channels in oxidized cholesterol membranes demonstrate that the voltage-dependent conductance of many-chanel membranes arises from two different mechanisms. These are the voltage-dependent redistribution of channels among several discrete single-channel conductance states themselves. The relaxation time for the discrete conductance changes is of the order of seconds nd the relaxation time of the continuous conductance changes is of the order 10(-4) seconds. As salt concentration in the bathing medium is increased, the single-channel conductance first increases lineary and then saturates. The characteristics of the saturation curves suggest that the continuous conductance changes occur at the edges of the channel and that the mean time an ion spends in the channel is 4 nanoseconds...
氧化胆固醇膜中单个血蓝蛋白通道的电反应表明，多通道膜的电压依赖性电导源于两种不同机制。这两种机制是通道在几个离散的单通道电导状态之间的电压依赖性重新分布。离散电导变化的弛豫时间约为秒级，而连续电导变化的弛豫时间约为10^(-4)秒。随着浴液介质中盐浓度的增加，单通道电导首先线性增加，然后饱和。饱和曲线的特征表明，连续电导变化发生在通道边缘，离子在通道中停留的平均时间为4纳秒……
