离子通道的静电建模。II. 膜偶极子电位的影响。
Electrostatic modeling of ion pores. II. Effects attributable to the membrane dipole potential.
作者信息
Jordan P C
出版信息
Biophys J. 1983 Feb;41(2):189-95. doi: 10.1016/S0006-3495(83)84419-1.
Abstract
This paper presents calculations of the shielded dipole potential in the interior of a pore piercing a lipid membrane that is at a potential V0 with respect to the aqueous solution. Except in the case of long narrow pores, there is substantial shielding of the membrane dipole potential. The associated dipole field never extends a significant distance into the aqueous region. The fact that the single-channel conductance of gramicidin B is only twice as large in glyceryl monooleate membranes as in phosphatidyl choline (PC) membranes, even though PC is approximately 120 mV more positive with respect to water, is interpreted in terms of the potential energy profile calculated for a gramicidin-like channel. It is demonstrated that the membrane dipole potential can significantly affect channel conductance only if the pore is narrow and if the peak in the potential energy profile occurs in the pore interior.
摘要
本文给出了在相对于水溶液处于电势V0的、贯穿脂质膜的孔内部的屏蔽偶极子电势的计算结果。除了狭长孔的情况外，膜偶极子电势存在显著的屏蔽。相关的偶极子场从未延伸到水相区域很远的距离。尽管相对于水，磷脂酰胆碱（PC）膜的电势大约比甘油单油酸酯膜正120 mV，但短杆菌肽B在甘油单油酸酯膜中的单通道电导仅为在PC膜中的两倍，这一事实根据为类短杆菌肽通道计算的势能分布来解释。结果表明，只有当孔很窄且势能分布的峰值出现在孔内部时，膜偶极子电势才会显著影响通道电导。
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