Bresler S, Kolikov V, Katushkina N, Molodkin V, Friedman E, Zheleznova H, Malafeieva L, Peradze T, Beljakov V, Ivanov K
Med Biol. 1975 Dec;53(6):456-61.
A chromatographic process has been developed for a mass purification and concentration of influenza virus. The final virus suspension, purified some 400 times, is characterized by its antigenic properties and protein content. The virus was killed by UV-light and the resulting vaccine tried on 345 people. The immunity level is 8 times higher than the control. In mice which were infected after immunization with a homologous and heterologous influenza virus strains a high protection index was found (10(6) EID50 for homologous and 10(4) EID50 for heterologous strains).
已开发出一种用于大规模纯化和浓缩流感病毒的色谱方法。最终的病毒悬液纯化了约400倍，其特征在于其抗原特性和蛋白质含量。该病毒经紫外线灭活，所得疫苗在345人身上进行了试验。免疫水平比对照组高8倍。在用同源和异源流感病毒株免疫后感染的小鼠中，发现了较高的保护指数（同源株为10(6) EID50，异源株为10(4) EID50）。
