Jovanovic D, Georges-Delvaux A M, Delem A
Dev Biol Stand. 1979;43:241-5.
Cost benefit estimates of immunization programs are critically dependent on an accurate and reliable assessment of the protection offered by the vaccines. Consequently, the selection of appropriate parameters of protection becomes an issue of major importance. The protective efficacy of live influenza virus vaccines has been established for several vaccinal strains used in routine immunization. This was established under conditions of natural and artificial exposure to both homologous and heterologous influenza viruses. Reduction in the incidence of specific disease--respiratory illness, confirmed by influenza virus isolation and/or four-fold increase in serum HAI titer, was found to be significant. These data will be discussed in relation to available epidemiological models that have been developed for the evaluation of disease modifying properties of immunoprophylactic agents.
免疫计划的成本效益评估严重依赖于对疫苗所提供保护的准确可靠评估。因此，选择合适的保护参数成为一个至关重要的问题。对于常规免疫中使用的几种疫苗株，已确定了活流感病毒疫苗的保护效力。这是在自然和人工暴露于同源和异源流感病毒的条件下确定的。通过流感病毒分离确诊的特定疾病（呼吸道疾病）发病率降低，和/或血清血凝抑制（HAI）效价四倍增加，被发现具有显著性。将结合已开发用于评估免疫预防剂疾病修饰特性的现有流行病学模型来讨论这些数据。
