Adler M, Goubau P, Nevens F, Van Vlierberghe H
Department of Gastroenterology and Hepatopancreatology, Hôpital Erasme, 808 route de Lennik, B-1070 Bruxelles, Belgique.
Acta Gastroenterol Belg. 2002 Apr-Jun;65(2):83-6.
Chronic hepatitis C infection affects approximately 3% of the world population and is responsible for a large proportion of patients with cirrhosis, end-stage liver diseases, hepatocellular carcinoma and for those who are candidates for liver transplantation or die of liver-related complications. The health care burden of this infection, whose epidemic peaked in the 1980s, is expected to significantly increase in the next 15 years in the absence of an organized national strategy. On the other hand, hepatitis C infection can be easily diagnosed with third generation enzyme immunoassay and indications for molecular biology-based assay are well defined. Composite scores and non-invasive markers of fibrosis may in the future replace liver biopsy which is still recommended in the presence of chronically elevated transaminases and indications for antiviral treatment.
慢性丙型肝炎感染影响着全球约3%的人口，导致很大一部分患者出现肝硬化、终末期肝病、肝细胞癌，并且是肝移植候选者或死于肝脏相关并发症的原因。这种感染的医疗负担在20世纪80年代达到流行高峰，在缺乏有组织的国家战略的情况下，预计未来15年将显著增加。另一方面，丙型肝炎感染可以通过第三代酶免疫测定轻松诊断，基于分子生物学测定的指征也已明确界定。纤维化的综合评分和非侵入性标志物未来可能会取代肝活检，不过在转氨酶长期升高及有抗病毒治疗指征的情况下，仍建议进行肝活检。
