Piccinni Marie-Pierre
Department of Internal Medicine, University of Florence, Italy.
Am J Reprod Immunol. 2002 May;47(5):289-94. doi: 10.1034/j.1600-0897.2002.01104.x.
Immunological mechanisms induced by T cells may play an important role in preimplantation embryo development, in implantation process and in the phenomenon of fetal allograft tolerance.
We review existing data on the role of T cells in pregnancy.
The production of LIF, interleukin (IL)-4, IL-10 and M-CSF by the decidual T cells may contribute to the maintenance of pregnancy. T cells are not only confined to the uterus. T cells are also present in cumulus oophorus and are able to produce LIF and IL-4.
These findings may provide an initial cue in favor of the possibility that different cytokines produced by T cells acting in concert are required to create a suitable microenvironment for the preimplantation embryo development and for the maintenance of pregnancy. T cells could work in parallel with other cells present in the decidua and cumulus suggesting a complex network of hormones, cytokines and cells.
T细胞诱导的免疫机制可能在植入前胚胎发育、着床过程以及胎儿同种异体移植耐受现象中发挥重要作用。
我们回顾了关于T细胞在妊娠中作用的现有数据。
蜕膜T细胞产生白血病抑制因子（LIF）、白细胞介素（IL）-4、IL-10和巨噬细胞集落刺激因子（M-CSF）可能有助于维持妊娠。T细胞不仅局限于子宫。T细胞也存在于卵丘中，并且能够产生LIF和IL-4。
这些发现可能为以下可能性提供初步线索，即T细胞产生的不同细胞因子协同作用，为植入前胚胎发育和维持妊娠创造合适的微环境是必要的。T细胞可能与蜕膜和卵丘中存在的其他细胞协同作用，提示存在一个由激素、细胞因子和细胞组成的复杂网络。
Zotero 插件