Krstic Jelena, Deutsch Alexander, Fuchs Julia, Gauster Martin, Gorsek Sparovec Tina, Hiden Ursula, Krappinger Julian Christopher, Moser Gerit, Pansy Katrin, Szmyra Marta, Gold Daniela, Feichtinger Julia, Huppertz Berthold
Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria.
Division of Hematology, Medical University of Graz, Stiftingtalstrasse 24, 8010 Graz, Austria.
Biomedicines. 2022 May 4;10(5):1065. doi: 10.3390/biomedicines10051065.
Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast cells invade maternal tissues while being tolerated by the maternal immune system. Similarly, tumor cells can invade surrounding tissues and escape the immune system. Importantly, both trophoblast and tumor cells are supported by an abetting microenvironment, which influences invasion, angiogenesis, and immune tolerance/evasion, among others. However, in contrast to tumor cells, the metabolic, proliferative, migrative, and invasive states of trophoblast cells are under tight regulatory control. In this review, we provide an overview of similarities and dissimilarities in regulatory processes that drive trophoblast and tumor cell fate, particularly focusing on the role of the abetting microenvironments.
胎盘特异性滋养层细胞和肿瘤细胞表现出许多共同特征。滋养层细胞侵入母体组织，同时被母体免疫系统所耐受。同样，肿瘤细胞也能侵入周围组织并逃避免疫系统。重要的是，滋养层细胞和肿瘤细胞都受到一个辅助性微环境的支持，该微环境会影响侵袭、血管生成以及免疫耐受/逃逸等过程。然而，与肿瘤细胞不同的是，滋养层细胞的代谢、增殖、迁移和侵袭状态受到严格的调控。在这篇综述中，我们概述了驱动滋养层细胞和肿瘤细胞命运的调控过程中的异同，尤其关注辅助性微环境的作用。
