Gungor Anil, Vural Cetin
Department of Pediatric Otolaryngology, Children's Hospital of Pittsburgh, 3705 Fifth Ave., Pittsburgh, PA 15213-2583, USA.
Ear Nose Throat J. 2002 Jul;81(7):449-53.
We conducted a study to test the accuracy of an immediate and delayed off-line technique for measuring nasal nitric oxide (NO) by comparing it with on-line measurements. With the assistance of one volunteer, we obtained these measurements during 30 sessions over a period of 2 months. Off-line measurements were made immediately following the acquisition of NO samples and 1, 2, and 4 hours later. NO samples were obtained from nasal air collected in syringes. We found that the correlation between on-line measurements and the immediate and delayed off-line measurements ranged from 95 to 98%, according to a Bland-Altman analysis. We conclude that off-line nasal NO measurements can be reliably used in clinical practice and research projects, thus obviating the need for patients/subjects to be in close proximity to the analyzer. Off-line nasal NO measurements can effectively substitute for on-line measurements when the latter technique is not practical.
我们开展了一项研究，通过将一种即时和延迟离线测量鼻一氧化氮（NO）的技术与在线测量进行比较，来测试该技术的准确性。在一名志愿者的协助下，我们在2个月的时间里进行了30次测量。离线测量在采集NO样本后立即进行，以及在1小时、2小时和4小时后进行。NO样本取自注射器收集的鼻腔空气。根据布兰德-奥特曼分析，我们发现在线测量与即时和延迟离线测量之间的相关性在95%至98%之间。我们得出结论，离线鼻NO测量可在临床实践和研究项目中可靠使用，从而无需患者/受试者靠近分析仪。当在线测量技术不可行时，离线鼻NO测量可有效替代在线测量。
