Ishida Junko, Kozuka Mutsuo, Tokuda Harukuni, Nishino Hoyoku, Nagumo Seiji, Lee Kuo Hsiung, Nagai Masahiro
Hoshi University, 2-4-41, Ebara, Shinagawa-ku, 142-8501, Tokyo, Japan.
Bioorg Med Chem. 2002 Oct;10(10):3361-5. doi: 10.1016/s0968-0896(02)00164-5.
Eleven cyclic diarylheptanoids and seven related compounds were screened as potential antitumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. In addition, the cyclic diarylheptanoid myricanone (2) was examined for antitumor initiating activity in a two-stage carcinogenesis assay of mouse skin tumors induced by peroxynitrite as an initiator and TPA as a promoter. Myricanone (2) exhibited significant antitumor-initiating effect on mouse skin. These data suggest that cyclic, as well as linear, diarylheptanoids might be valuable chemopreventors.
