鼻相关淋巴组织（NALT）器官发生的起始不依赖于白细胞介素-7受体（IL-7R）、淋巴毒素β受体（LTβR）和NF-κB诱导激酶（NIK）信号通路，但需要Id2基因和CD3(-)CD4(+)CD45(+)细胞。
Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells.
作者信息
Fukuyama Satoshi, Hiroi Takachika, Yokota Yoshifumi, Rennert Paul D, Yanagita Manabu, Kinoshita Naotoshi, Terawaki Seigo, Shikina Takashi, Yamamoto Masafumi, Kurono Yuichi, Kiyono Hiroshi
机构信息
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
出版信息
Immunity. 2002 Jul;17(1):31-40. doi: 10.1016/s1074-7613(02)00339-4.
Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent of the programmed cytokine cascade necessary for the formation of Peyer's patches (PP) and peripheral lymph nodes (PLN), a cytokine cascade which consists of IL-7R, LTalpha1beta2/LTbetaR, and NIK. However, the subsequent organization of NALT seems to be controlled by these cytokine signaling cascades since the maturation of NALT structure is generally incomplete in those cytokine cascade-deficient mice. NALT as well as PP and PLN are completely absent in Id2(-/-) mice. NALT organogenesis is initiated following the adoptive transfer of CD3(-)CD4(+)CD45(+) cells into Id2(-/-) mice, constituting direct evidence that CD3(-)CD4(+)CD45(+) inducer cells can provide an IL-7R-, LTalpha1beta2/LTbetaR-, and NIK-independent tissue organogenesis pathway for secondary lymphoid tissue development.
鼻咽相关淋巴组织（NALT）发育的起始独立于派尔集合淋巴结（PP）和外周淋巴结（PLN）形成所必需的程序性细胞因子级联反应，该细胞因子级联反应由IL-7R、LTα1β2/LTβR和NIK组成。然而，NALT随后的组织形成似乎受这些细胞因子信号级联反应的控制，因为在那些细胞因子级联反应缺陷的小鼠中，NALT结构的成熟通常是不完全的。Id2（-/-）小鼠中完全不存在NALT以及PP和PLN。将CD3（-）CD4（+）CD45（+）细胞过继转移到Id2（-/-）小鼠后，NALT器官发生开始，这构成了直接证据，即CD3（-）CD4（+）CD45（+）诱导细胞可为次级淋巴组织发育提供一条独立于IL-7R、LTα1β2/LTβR和NIK的组织器官发生途径。
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