树突状细胞通过B淋巴细胞刺激因子（BLyS）和增殖诱导配体（APRIL）诱导不依赖CD40的免疫球蛋白类别转换。
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.
作者信息
Litinskiy Mikhail B, Nardelli Bernardetta, Hilbert David M, He Bing, Schaffer Andras, Casali Paolo, Cerutti Andrea
机构信息
Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.
出版信息
Nat Immunol. 2002 Sep;3(9):822-9. doi: 10.1038/ni829. Epub 2002 Aug 5.
Abstract
Immunoglobulin (Ig) class-switch DNA recombination (CSR) is thought to be highly dependent upon engagement of CD40 on B cells by CD40 ligand on T cells. We show here that dendritic cells up-regulate BLyS and APRIL upon exposure to interferon-alpha, interferon-gamma or CD40 ligand. In the presence of interleukin 10 (IL-10) or transforming growth factor-beta, BLyS and APRIL induce CSR from C(mu) to C(gamma) and/or C(alpha) genes in B cells, whereas CSR to C(epsilon) requires IL-4. Secretion of class-switched antibodies requires additional stimulation by B cell antigen receptor engagement and IL-15. By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses.
摘要
免疫球蛋白（Ig）类别转换DNA重组（CSR）被认为高度依赖于T细胞上的CD40配体与B细胞上的CD40结合。我们在此表明，树突状细胞在暴露于α干扰素、γ干扰素或CD40配体后会上调B淋巴细胞刺激因子（BLyS）和增殖诱导配体（APRIL）。在白细胞介素10（IL-10）或转化生长因子-β存在的情况下，BLyS和APRIL可诱导B细胞中从Cμ到Cγ和/或Cα基因的类别转换，而向Cε的类别转换则需要IL-4。类别转换抗体的分泌需要通过B细胞抗原受体结合和IL-15进行额外刺激。通过引发不依赖CD40的Ig类别转换和浆细胞样分化，BLyS和APRIL将先天性免疫反应和适应性免疫反应紧密联系起来。
相似文献
1
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.树突状细胞通过B淋巴细胞刺激因子（BLyS）和增殖诱导配体（APRIL）诱导不依赖CD40的免疫球蛋白类别转换。
Nat Immunol. 2002 Sep;3(9):822-9. doi: 10.1038/ni829. Epub 2002 Aug 5.
2
EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching.EB病毒编码的潜伏膜蛋白1与B细胞活化因子/ B淋巴细胞刺激因子（BAFF/BLyS）及增殖诱导配体（APRIL）协同作用，以诱导不依赖T细胞的Ig重链类别转换。
J Immunol. 2003 Nov 15;171(10):5215-24. doi: 10.4049/jimmunol.171.10.5215.
3
CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10.CpG DNA通过一种需要TLR9并与IL-10协同作用的固有途径激活人B细胞，从而诱导IgG类别转换DNA重组。
J Immunol. 2004 Oct 1;173(7):4479-91. doi: 10.4049/jimmunol.173.7.4479.
4
BLySsful interactions between DCs and B cells.树突状细胞与B细胞之间的有益相互作用。
Nat Immunol. 2002 Sep;3(9):798-800. doi: 10.1038/ni0902-798.
5
B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses.B细胞的Toll样受体1/2、Toll样受体4、Toll样受体7和Toll样受体9在类别转换DNA重组的诱导过程中相互作用：受B细胞受体和CD40调节及其与非T细胞依赖性抗体应答的相关性
Autoimmunity. 2015 Feb;48(1):1-12. doi: 10.3109/08916934.2014.993027.
6
CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination.CD40激活通过内源性转化生长因子β（TGF-β）的诱导促使人类B细胞转换为IgA1和IgA2：支持TGF-β而非白细胞介素10依赖性直接的Smu→Sα以及连续的Smu→Sγ、Sγ→Sα DNA重组的证据。
J Immunol. 1998 Nov 15;161(10):5217-25.
7
8
Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells.CD30 + T细胞与CD153（CD30配体）结合可抑制人IgD + IgM + B细胞中的类别转换DNA重组和抗体产生。
J Immunol. 2000 Jul 15;165(2):786-94. doi: 10.4049/jimmunol.165.2.786.
9
HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors.HIV-1包膜蛋白通过一种不依赖CD40的机制触发多克隆Ig类别转换重组，该机制涉及BAFF和C型凝集素受体。
J Immunol. 2006 Apr 1;176(7):3931-41. doi: 10.4049/jimmunol.176.7.3931.
10
B lymphocyte stimulator activates p38 mitogen-activated protein kinase in human Ig class switch recombination.B淋巴细胞刺激因子在人类免疫球蛋白类别转换重组中激活p38丝裂原活化蛋白激酶。
Am J Respir Cell Mol Biol. 2005 May;32(5):388-94. doi: 10.1165/rcmb.2004-0317OC. Epub 2005 Jan 24.
引用本文的文献
1
Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications.树突状细胞：了解其个体发育、亚群、功能及其临床应用。
Mol Biomed. 2025 Sep 8;6(1):62. doi: 10.1186/s43556-025-00300-8.
2
Similarities and differences of a proliferation-inducing ligand expression in lacrimal gland lesions of patients with IgG4-associated ophthalmic diseases and mucosa-associated lymphoid tissue lymphoma.IgG4相关性眼病患者泪腺病变及黏膜相关淋巴组织淋巴瘤中增殖诱导配体表达的异同
Front Immunol. 2025 Feb 18;16:1514003. doi: 10.3389/fimmu.2025.1514003. eCollection 2025.
3
Role of cellular effectors in the induction and maintenance of IgA responses leading to protective immunity against enteric bacterial pathogens.细胞效应因子在诱导和维持 IgA 反应中的作用，这些反应导致对肠道细菌病原体的保护性免疫。
Front Immunol. 2024 Sep 11;15:1446072. doi: 10.3389/fimmu.2024.1446072. eCollection 2024.
4
Targeting TNF/TNFR superfamilies in immune-mediated inflammatory diseases.针对免疫介导的炎症性疾病中的 TNF/TNFR 超家族。
J Exp Med. 2024 Nov 4;221(11). doi: 10.1084/jem.20240806. Epub 2024 Sep 19.
5
Pathogenic Immunoglobulin A-Producing Cells in Immunoglobulin A Nephropathy.IgA肾病中产生致病性免疫球蛋白A的细胞
J Clin Med. 2024 Sep 5;13(17):5255. doi: 10.3390/jcm13175255.
6
BAFF neutralization impairs the autoantibody-mediated clearance of dead adipocytes and aggravates obesity-induced insulin resistance.阻断 BAFF 可损害由自身抗体介导的死亡脂肪细胞的清除，从而加重肥胖引起的胰岛素抵抗。
Front Immunol. 2024 Aug 9;15:1436900. doi: 10.3389/fimmu.2024.1436900. eCollection 2024.
7
Lrba participates in the differentiation of IgA+ B lymphocytes through TGFβR signaling.Lrba 通过 TGFβR 信号参与 IgA+B 淋巴细胞的分化。
Front Immunol. 2024 Jun 21;15:1386260. doi: 10.3389/fimmu.2024.1386260. eCollection 2024.
8
Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue.双阴性 B 细胞和 DNASE1L3 与肠道相关淋巴组织中的微生物群共定位。
Nat Commun. 2024 May 14;15(1):4051. doi: 10.1038/s41467-024-48267-4.
9
The PD-1/PD-L1 Axis in the Biology of MASLD.PD-1/PD-L1 轴在 MASLD 生物学中的作用。
Int J Mol Sci. 2024 Mar 25;25(7):3671. doi: 10.3390/ijms25073671.
10
The role of BAFF and APRIL in IgA nephropathy: pathogenic mechanisms and targeted therapies.BAFF和APRIL在IgA肾病中的作用：致病机制与靶向治疗
Front Nephrol. 2024 Feb 1;3:1346769. doi: 10.3389/fneph.2023.1346769. eCollection 2023.
本文引用的文献
1
APRIL modulates B and T cell immunity.增殖诱导配体调节B细胞和T细胞免疫。
J Clin Invest. 2002 Jun;109(12):1587-98. doi: 10.1172/JCI15034.
2
The mechanism and regulation of chromosomal V(D)J recombination.染色体V(D)J重组的机制与调控。
Cell. 2002 Apr;109 Suppl:S45-55. doi: 10.1016/s0092-8674(02)00675-x.
3
Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity.免疫球蛋白基因的体细胞超突变：遗传多样性的融合机制
Cell. 2002 Apr;109 Suppl:S35-44. doi: 10.1016/s0092-8674(02)00706-7.
4
The AID enzyme induces class switch recombination in fibroblasts.AID酶可诱导成纤维细胞发生类别转换重排。
Nature. 2002 Mar 21;416(6878):340-5. doi: 10.1038/nature727. Epub 2002 Mar 3.
5
Mechanism and control of class-switch recombination.类别转换重组的机制与调控。
Trends Immunol. 2002 Jan;23(1):31-9. doi: 10.1016/s1471-4906(01)02111-1.
6
Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.干扰素-α在系统性红斑狼疮中诱导树突状细胞分化
Science. 2001 Nov 16;294(5546):1540-3. doi: 10.1126/science.1064890.
7
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria.肠道固有层中发生原位类别转换并分化为产生IgA的细胞。
Nature. 2001 Oct 11;413(6856):639-43. doi: 10.1038/35098100.
8
A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs.活跃的类别转换重组的一个标志：由环状DNA上的I启动子指导的转录本。
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12620-3. doi: 10.1073/pnas.221454398. Epub 2001 Oct 16.
9
Human genetic defects in class-switch recombination (hyper-IgM syndromes).类别转换重组中的人类遗传缺陷（高IgM综合征）。
Curr Opin Immunol. 2001 Oct;13(5):543-8. doi: 10.1016/s0952-7915(00)00256-9.
10
TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS.跨膜激活物和钙调亲环素配体相互作用分子免疫球蛋白（TACI-Ig）可中和对B细胞发育和自身免疫性疾病至关重要的分子。在缺乏B淋巴细胞刺激因子（BLyS）的小鼠中，B细胞成熟受损。
Immunity. 2001 Aug;15(2):289-302. doi: 10.1016/s1074-7613(01)00183-2.
Zotero 插件