前列腺素E1、E2、F1α和F2α对豚鼠回肠和结肠蠕动的影响。
The effects of prostaglandins E1, E2, F1alpha and F2alpha on guinea-pig ileal and colonic peristalis.
作者信息
Eley K G, Bennett A, Stockley H L
出版信息
J Pharm Pharmacol. 1977 May;29(5):276-80. doi: 10.1111/j.2042-7158.1977.tb11311.x.
Prostaglandins (PGE1, E2, F1alpha and F2alpha) have been tested on the peristaltic reflex in isolated segments of guinea-pig ileum and colon using simultaneous recordings of fluid propulsion and longitudinal and circular muscle activity. Propulsion and circular muscle peristaltic activity were increased by serosally applied PGF compounds in the ileum and PGE or PGF compounds in the colon following initial contraction of the longitudinal muscle. This is consistent with a role for prostaglandins in peristalsis. Mucosally applied PGF compounds has no significant effect.
使用流体推进以及纵肌和环肌活动的同步记录，对前列腺素（PGE1、E2、F1α和F2α）在豚鼠回肠和结肠离体节段的蠕动反射进行了测试。在纵肌初始收缩后，在回肠中通过浆膜应用PGF化合物以及在结肠中通过应用PGE或PGF化合物，推进和环肌蠕动活动增强。这与前列腺素在蠕动中发挥作用一致。通过黏膜应用PGF化合物没有显著影响。
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