Weinstein L, Droegemueller W, Cornette J, Greer B, Gutknecht G
South Med J. 1979 Sep;72(9):1159-60. doi: 10.1097/00007611-197909000-00024.
A single intra-amniotic injection of (15S)-15 methyl prostaglandin F2 alpha (THAM) was used to induce second trimester abortion in five patients. Serial levels of (15S)-15 methyl prostaglandin F2 alpha were subsequently measured in amniotic fluid and plasma by radioimmunoassay. The slow removal of this drug from the amniotic fluid was documented. Plasma levels of (15S)-15 methyl prostaglandin F2 alpha increased fourfold to sevenfold after clinical rupture of the membranes in three patients, supporting the fact that prostaglandins are well absorbed from the vagina. Because this analogue of prostaglandin can cause marked peripheral bronchoconstriction when administered systemically, it is best to avoid its use in patients with a history of asthma.
单次羊膜腔内注射（15S）-15-甲基前列腺素F2α（THAM）用于诱导5例中期妊娠患者流产。随后通过放射免疫分析法测定羊水和血浆中（15S）-15-甲基前列腺素F2α的系列水平。记录了该药物从羊水中缓慢清除的情况。3例患者胎膜临床破裂后，血浆中（15S）-15-甲基前列腺素F2α水平增加了4倍至7倍，这支持了前列腺素可从阴道良好吸收的事实。由于这种前列腺素类似物全身给药时可引起明显的外周支气管收缩，因此最好避免在有哮喘病史的患者中使用。
