前列腺素在豚鼠离体回肠吗啡依赖性表达中的可能作用。
A possible role for prostaglandins in the expression of morphine dependence in guinea-pig isolated ileum.
作者信息
Johnson M A, Hill R G, Hughes J
机构信息
Parke-Davis Research Unit, Addenbrookes Hospital Site, Cambridge.
出版信息
Br J Pharmacol. 1988 Apr;93(4):932-6. doi: 10.1111/j.1476-5381.1988.tb11482.x.
Abstract
- The effects of the cyclo-oxygenase inhibitors, indomethacin (1.3 microM) and mefenamic acid (10 microM), were investigated on the naloxone-precipitated withdrawal contracture of the morphine-dependent guinea-pig ileum in vitro. 2. Both indomethacin and mefenamic acid prevented expression of the withdrawal contracture on naloxone challenge. 3. The effects of indomethacin were reversed by the concurrent application of a low dose of prostaglandin E1 (10 nM). 4. It was concluded that prostaglandins probably play a role in the expression of morphine withdrawal in this model.
摘要
- 研究了环氧化酶抑制剂吲哚美辛（1.3微摩尔）和甲芬那酸（10微摩尔）对纳洛酮诱发的吗啡依赖豚鼠离体回肠戒断挛缩的影响。2. 吲哚美辛和甲芬那酸均可阻止纳洛酮激发时戒断挛缩的表现。3. 同时应用低剂量前列腺素E1（10纳摩尔）可逆转吲哚美辛的作用。4. 得出结论：在该模型中，前列腺素可能在吗啡戒断表现中起作用。
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本文引用的文献
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Cyclo-oxygenase inhibitors antagonize indirectly evoked contractions of the guinea-pig isolated ileum by inhibiting acetylcholine release.环氧化酶抑制剂通过抑制乙酰胆碱释放来间接拮抗豚鼠离体回肠的诱发收缩。
Br J Pharmacol. 1984 Jul;82(3):577-85. doi: 10.1111/j.1476-5381.1984.tb10796.x.
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Manifestations of gut opiate withdrawal contracture and its blockade by capsaicin.
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Contracture of guinea-pig ileum on withdrawal of methionine5-enkephalin is mediated by substance P.蛋氨酸脑啡肽撤除后豚鼠回肠的挛缩由P物质介导。
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Prostaglandins reverse inhibition of electrically-induced contractions of guinea pig ileum by morphine, indomethacin and acetylsalicylic acid.前列腺素可逆转吗啡、吲哚美辛和乙酰水杨酸对豚鼠回肠电诱导收缩的抑制作用。
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