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A possible role for prostaglandins in the expression of morphine dependence in guinea-pig isolated ileum.前列腺素在豚鼠离体回肠吗啡依赖性表达中的可能作用。
Br J Pharmacol. 1988 Apr;93(4):932-6. doi: 10.1111/j.1476-5381.1988.tb11482.x.
2
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3
Inhibition by indomethacin of naloxone-precipitated opiate withdrawal contraction in isolated guinea pig myenteric plexus-longitudinal muscle preparation.吲哚美辛对豚鼠离体肠肌丛-纵肌标本中纳洛酮诱发的阿片戒断收缩的抑制作用。
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Selective potentiation by ouabain of naloxone-induced withdrawal contractions of isolated guinea-pig ileum following acute exposure to morphine.急性暴露于吗啡后，哇巴因对纳洛酮诱导的离体豚鼠回肠戒断收缩的选择性增强作用。
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Cyclo-oxygenase inhibitors antagonize indirectly evoked contractions of the guinea-pig isolated ileum by inhibiting acetylcholine release.环氧化酶抑制剂通过抑制乙酰胆碱释放来间接拮抗豚鼠离体回肠的诱发收缩。
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引用本文的文献

1
Interactions between cholecystokinin and opioids in the isolated guinea-pig ileum.胆囊收缩素与阿片类药物在离体豚鼠回肠中的相互作用。
Br J Pharmacol. 1999 Jun;127(4):909-18. doi: 10.1038/sj.bjp.0702621.

本文引用的文献

1
Model of opiate dependence in the guinea-pig isolated ileum.豚鼠离体回肠阿片类药物依赖模型。
Br J Pharmacol. 1981 Aug;73(4):921-32. doi: 10.1111/j.1476-5381.1981.tb08747.x.
2
Cyclo-oxygenase inhibitors antagonize indirectly evoked contractions of the guinea-pig isolated ileum by inhibiting acetylcholine release.环氧化酶抑制剂通过抑制乙酰胆碱释放来间接拮抗豚鼠离体回肠的诱发收缩。
Br J Pharmacol. 1984 Jul;82(3):577-85. doi: 10.1111/j.1476-5381.1984.tb10796.x.
3
Manifestations of gut opiate withdrawal contracture and its blockade by capsaicin.
Eur J Pharmacol. 1982 Jul 16;81(3):377-83. doi: 10.1016/0014-2999(82)90102-9.
4
Contracture of guinea-pig ileum on withdrawal of methionine5-enkephalin is mediated by substance P.蛋氨酸脑啡肽撤除后豚鼠回肠的挛缩由P物质介导。
Br J Pharmacol. 1983 Dec;80(4):741-9. doi: 10.1111/j.1476-5381.1983.tb10066.x.
5
Prostaglandins reverse inhibition of electrically-induced contractions of guinea pig ileum by morphine, indomethacin and acetylsalicylic acid.前列腺素可逆转吗啡、吲哚美辛和乙酰水杨酸对豚鼠回肠电诱导收缩的抑制作用。
Nat New Biol. 1973 Oct 31;245(148):280-2. doi: 10.1038/newbio245280a0.
6
A modulating role of prostaglandins in contractions of the guinea-pig ileum.前列腺素在豚鼠回肠收缩中的调节作用。
Br J Pharmacol. 1974 Aug;51(4):565-70. doi: 10.1111/j.1476-5381.1974.tb09675.x.
7
Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.吗啡类药物可抑制大鼠脑匀浆对环磷腺苷形成的E前列腺素的刺激作用。
Nature. 1974 Mar 1;248(5443):24-7. doi: 10.1038/248024a0.
8
Inhibition by indomethacin of naloxone-precipitated opiate withdrawal contraction in isolated guinea pig myenteric plexus-longitudinal muscle preparation.吲哚美辛对豚鼠离体肠肌丛-纵肌标本中纳洛酮诱发的阿片戒断收缩的抑制作用。
Life Sci. 1986 Jul 21;39(3):243-7. doi: 10.1016/0024-3205(86)90537-0.
9
Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells.花生四烯酸的脂氧合酶代谢产物作为海兔感觉细胞突触前抑制的第二信使。
Nature. 1987;328(6125):38-43. doi: 10.1038/328038a0.

前列腺素在豚鼠离体回肠吗啡依赖性表达中的可能作用。

A possible role for prostaglandins in the expression of morphine dependence in guinea-pig isolated ileum.

作者信息

Johnson M A, Hill R G, Hughes J

机构信息

Parke-Davis Research Unit, Addenbrookes Hospital Site, Cambridge.

出版信息

Br J Pharmacol. 1988 Apr;93(4):932-6. doi: 10.1111/j.1476-5381.1988.tb11482.x.

DOI:10.1111/j.1476-5381.1988.tb11482.x
PMID:3134073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1853880/
Abstract
  1. The effects of the cyclo-oxygenase inhibitors, indomethacin (1.3 microM) and mefenamic acid (10 microM), were investigated on the naloxone-precipitated withdrawal contracture of the morphine-dependent guinea-pig ileum in vitro. 2. Both indomethacin and mefenamic acid prevented expression of the withdrawal contracture on naloxone challenge. 3. The effects of indomethacin were reversed by the concurrent application of a low dose of prostaglandin E1 (10 nM). 4. It was concluded that prostaglandins probably play a role in the expression of morphine withdrawal in this model.
摘要
  1. 研究了环氧化酶抑制剂吲哚美辛（1.3微摩尔）和甲芬那酸（10微摩尔）对纳洛酮诱发的吗啡依赖豚鼠离体回肠戒断挛缩的影响。2. 吲哚美辛和甲芬那酸均可阻止纳洛酮激发时戒断挛缩的表现。3. 同时应用低剂量前列腺素E1（10纳摩尔）可逆转吲哚美辛的作用。4. 得出结论：在该模型中，前列腺素可能在吗啡戒断表现中起作用。