Singh Chandan, Srivastav Naveen Chandra, Puri Sunil K
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Bioorg Med Chem Lett. 2002 Sep 2;12(17):2277-9. doi: 10.1016/s0960-894x(02)00457-2.
Building on the lead from antimalarial isonitriles 1-4 of marine origin, several easily accessible synthetic isonitriles were assessed for their antimalarial activity against Plasmodium falciparum (in vitro) and multidrug resistant Plasmodium yoelii in Swiss mice model (in vivo). Isonitrile 11 has shown promising activity in both these assays.
基于源自海洋的抗疟异腈1-4的研究成果，对几种易于获取的合成异腈进行了评估，以检测它们对恶性疟原虫（体外）和瑞士小鼠模型中多药耐药的约氏疟原虫（体内）的抗疟活性。异腈11在这两种试验中均显示出有前景的活性。
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