Susheela A K, Bhatnagar Madhu
Fluorosis Research and Rural Development Foundation, Delhi, India.
Mol Cell Biochem. 2002 May-Jun;234-235(1-2):335-40.
The objective of the present communication is to address the issues concerning reversal of fluoride induced cell injury and disease (i.e. fluorosis) through the elimination of fluoride and consumption of a diet containing essential nutrients and antioxidants. Humans afflicted with fluorosis, as a result of consuming fluoride contaminated water or food, have been investigated. Hospital based diagnostic procedure for early detection of fluorosis, through retrieval of history, clinical complaints, testing of blood, urine and drinking water for fluoride using ion selective electrode technology, along with X-ray of the forearm have been carried out. Confirmed cases of fluorosis were introduced to an intervention protocol consisting of (1) provision of safe drinking water with fluoride levels less than 1 mg/L and (2) counselling on nutritional supplementation with focus on adequate intake of calcium, vitamins C, E and antioxidants. The patients were monitored at frequent intervals up to one year and the results are reported. With a standardized early diagnosis, elimination of fluoride intake and supplementation of a diet rich in essential nutrients and antioxidants, we have shown that the fluorosis can be reversed.
本通讯的目的是通过消除氟化物并食用含有必需营养素和抗氧化剂的饮食，来解决与氟化物诱导的细胞损伤和疾病（即氟中毒）逆转相关的问题。对因饮用受氟化物污染的水或食物而患氟中毒的人群进行了调查。通过询问病史、临床症状，使用离子选择电极技术检测血液、尿液和饮用水中的氟化物，并结合前臂X线检查，开展了基于医院的氟中毒早期诊断程序。确诊的氟中毒病例被纳入一个干预方案，该方案包括：（1）提供氟化物含量低于1mg/L的安全饮用水；（2）提供营养补充咨询，重点是保证充足的钙、维生素C、维生素E和抗氧化剂摄入。对患者进行了长达一年的定期监测并报告结果。通过标准化的早期诊断、消除氟化物摄入以及补充富含必需营养素和抗氧化剂的饮食，我们已证明氟中毒是可以逆转的。
