Dasarathy S, Das T K, Gupta I P, Susheela A K, Tandon R K
Department of Gastroenterology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
J Gastroenterol. 1996 Jun;31(3):333-7. doi: 10.1007/BF02355021.
A prospective case-controlled study was performed to evaluate the gastrointestinal symptoms and mucosal abnormalities occurring in patients with osteofluorosis. Ten patients with documented osteofluorosis and ten age- and sex-matched healthy volunteers were included in the study. Clinical evaluation, real-time ultrasound, and upper gastrointestinal endoscopy and biopsy from the gastric antrum and duodenum were performed in all subjects. The biopsies were subjected to a rapid urease test and light and electron microscopic examinations. Ionic fluoride levels were estimated in the drinking water, serum, and urine using an ION 85 ion analyzer. All patients with osteofluorosis had gastrointestinal symptoms, the most common being abdominal pain. Endoscopic abnormalities were found in seven patients with osteofluorosis. In all 7 of these patients, chronic atrophic gastritis was seen on histology. Electron microscopic abnormalities were observed in all 10 patients with osteofluorosis. These included loss of microvilli, cracked-clay appearance, and the presence of surface abrasions on the mucosal cells. None of the control subjects had any clinical symptoms or mucosal abnormalities. It was concluded that gastrointestinal symptoms as well as mucosal abnormalities are common in patients with osteofluorosis.
进行了一项前瞻性病例对照研究，以评估氟骨症患者出现的胃肠道症状和黏膜异常。该研究纳入了10例有记录的氟骨症患者以及10名年龄和性别匹配的健康志愿者。对所有受试者进行了临床评估、实时超声检查以及胃窦和十二指肠的上消化道内镜检查及活检。活检组织进行了快速尿素酶试验以及光镜和电镜检查。使用ION 85离子分析仪测定饮用水、血清和尿液中的离子氟水平。所有氟骨症患者均有胃肠道症状，最常见的是腹痛。7例氟骨症患者发现内镜异常。在这7例患者中，组织学检查均可见慢性萎缩性胃炎。所有10例氟骨症患者均观察到电镜异常。这些异常包括微绒毛缺失、龟裂样外观以及黏膜细胞表面擦伤。对照组受试者均无任何临床症状或黏膜异常。研究得出结论，胃肠道症状以及黏膜异常在氟骨症患者中很常见。
