Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
BMC Oral Health. 2024 Sep 8;24(1):1050. doi: 10.1186/s12903-024-04807-4.
Fluoride plays a vital role in preventing dental caries, with its addition to oral care products significantly promoting oral hygiene. A no-rinse brushing method aims to increase fluoride retention in the oral cavity, as rinsing with water decreases fluoride levels in saliva, which could affect remineralization. While the no-rinse brushing method holds promise for improving fluoride retention in the oral cavity, critical inquiries persist regarding its safety. This study investigated the kinetics of oral fluoride and potential risks to fully assess its effectiveness and implications for oral health.
Ten healthy adults participated in a crossover study comparing the no-rinse with the rinse method. All subjects followed American Dental Association (ADA) brushing guidelines. Levels of fluoride in saliva (supernatant and sediment) and urine were measured over time, and plasma fluoride was measured one hour after brushing. Pharmacokinetic parameters were also calculated from the data.
Participants using the no-rinse method had higher fluoride levels in supernatant immediately and up to 30 min post-brushing compared to the rinse method. Fluoride levels in sediment were higher only immediately after brushing. The total fluoride concentration in saliva remained elevated for up to 5 min with the no-rinse method. Systemic fluoride absorption showed no significant difference between the two methods based on blood and urine analysis.
This research indicates that the no-rinse method can enhance fluoride retention in the oral cavity for up to 30 min after a single brushing. In addition, our findings suggest that this method does not significantly influence systemic fluoride levels or toxicity.
Thai Clinical Trials Registry, TCTR ( http://thaiclinicaltrials.org ).
TCTR20231104001 (4/11/2023).
氟化物在预防龋齿方面起着至关重要的作用，将其添加到口腔护理产品中显著促进了口腔卫生。免冲洗刷牙法旨在增加口腔中氟化物的保留，因为用水冲洗会降低唾液中的氟化物水平，从而影响再矿化。虽然免冲洗刷牙法有望提高口腔中氟化物的保留，但对其安全性仍存在关键质疑。本研究调查了口腔氟化物的动力学和潜在风险，以全面评估其有效性及其对口腔健康的影响。
10 名健康成年人参与了一项交叉研究，比较了免冲洗与冲洗方法。所有受试者均遵循美国牙科协会（ADA）的刷牙指南。在不同时间测量唾液（上清液和沉淀物）和尿液中的氟化物水平，并在刷牙后 1 小时测量血浆氟化物。还从数据中计算了药代动力学参数。
与冲洗方法相比，使用免冲洗方法的参与者在刷牙后立即和 30 分钟内，上清液中的氟化物水平更高。仅在刷牙后，沉淀物中的氟化物水平更高。使用免冲洗方法，唾液中的总氟化物浓度在 5 分钟内保持升高。基于血液和尿液分析，两种方法之间的全身氟化物吸收没有显著差异。
本研究表明，单次刷牙后，免冲洗方法可以将口腔中氟化物的保留时间延长至 30 分钟。此外，我们的发现表明，这种方法不会显著影响全身氟化物水平或毒性。
泰国临床试验注册中心，TCTR（http://thaiclinicaltrials.org）。
TCTR20231104001（2023 年 11 月 4 日）。
