Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Munich, Germany.
J Nucl Med. 2011 Apr;52(4):617-24. doi: 10.2967/jnumed.110.083196.
The novel PET flow tracer flurpiridaz F 18 shows high myocardial extraction and slow washout. flurpiridaz F 18 PET data analysis with tracer kinetic modeling provides accurate absolute myocardial blood flow (MBF) measurements but requires in-scanner injection and complex processing. We evaluated the hypothesis that myocardial retention and standardized uptake values (SUVs) based on late uptake provide accurate estimates of myocardial flow reserve (MFR) and, thus, might allow simplified quantification after tracer injection outside the scanner.
Nine pigs had dynamic PET scans after repeated injections of flurpiridaz F 18 at rest and combined adenosine and dobutamine stress. flurpiridaz F 18 PET with a 3-compartment model and coinjected radioactive microspheres were used to delineate MBF. These quantitative measurements were compared with myocardial retention (%/min) and SUV of flurpiridaz F 18 after summing data over 5-10, 5-12, 5-15, 10-15, and 10-20 min after tracer injection.
MBF ranged from 0.5 to 2.8 mL/min/g. There was a good correlation between both flurpiridaz F 18 retention and SUVs from 5 to 12 min after injection and MBF measured using 3-compartment model- or microsphere-derived MBF (r = 0.73, P < 0.05, and r = 0.68, P < 0.05, respectively, for retention; r = 0.88, P < 0.001, and r = 0.92, P < 0.001, respectively, for SUV). At later time points, retention and SUV underestimated stress microsphere flow (at 10-20 min: r = 0.41, P = not significant, and r = 0.46, P = not significant, respectively, for retention; r = 0.41, P = not significant, and r = 0.65, P < 0.05, respectively, for SUV). When measured 5-12 min after injection, there was a close agreement between MFR measured with either flurpiridaz F 18 retention or SUV and MFR measured using microspheres (mean difference, -0.08 ± 0.36 and -0.18 ± 0.25, respectively).
Myocardial retention and SUVs of the (18)F-labeled flow tracer flurpiridaz F 18 accurately reflect the MFR. These simplified analysis methods may facilitate the combination of quantitative assessment of perfusion reserve and rapid clinical imaging protocols.
本研究旨在评估基于延迟摄取的放射性示踪剂摄取和标准化摄取比值（SUV）是否可用于简化扫描外注射示踪剂后的定量分析，并提供准确的心肌血流储备（MFR）评估。
9 头猪在静息和腺苷及多巴酚丁胺联合负荷下进行多次氟比拉嗪 F18 动态 PET 扫描。氟比拉嗪 F18 的 PET 采用三房室模型，与同时注射的放射性微球一起用于描绘 MBF。这些定量测量结果与氟比拉嗪 F18 在注射后 5-10、5-12、5-15、10-15 和 10-20 分钟时的放射性示踪剂摄取的百分数/分钟（%/min）和 SUV 进行了比较。
MBF 范围为 0.5 至 2.8 毫升/分钟/克。氟比拉嗪 F18 的摄取和 SUV 与使用三房室模型或微球衍生的 MBF 测量的 MBF 在注射后 5 至 12 分钟时均有良好的相关性（r = 0.73，P < 0.05，r = 0.68，P < 0.05，分别为摄取；r = 0.88，P < 0.001，r = 0.92，P < 0.001，分别为 SUV）。在较晚的时间点，摄取和 SUV 低估了应激微球的血流（在 10-20 分钟时：r = 0.41，P = 无显著意义，r = 0.46，P = 无显著意义，分别为摄取；r = 0.41，P = 无显著意义，r = 0.65，P < 0.05，分别为 SUV）。当在注射后 5-12 分钟时测量时，使用氟比拉嗪 F18 摄取或 SUV 测量的 MFR 与使用微球测量的 MFR 之间存在密切的一致性（平均差值，-0.08 ± 0.36 和 -0.18 ± 0.25）。
氟比拉嗪 F18 的放射性示踪剂摄取和 SUV 准确反映了 MFR。这些简化的分析方法可能有助于结合灌注储备的定量评估和快速临床成像方案。
