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给予酒精和尼古丁会抑制幼鼠背侧和中缝核中5-羟色胺的合成及色氨酸羟化酶的表达。

Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats.

作者信息

Jang Mi-Hyeon, Shin Min-Chul, Lee Taeck-Hyun, Kim Young-Pyo, Jung Sae-Bin, Shin Dong-Hoon, Kim Hong, Kim Sung-Soo, Kim Ee-Hwa, Kim Chang-Ju

机构信息

Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea.

出版信息

Neurosci Lett. 2002 Aug 30;329(2):141-4. doi: 10.1016/s0304-3940(02)00622-5.

DOI:10.1016/s0304-3940(02)00622-5
PMID:12165397
Abstract

Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT synthesis, in the dorsal and median raphe of young rats were investigated via immunohistochemistry. The numbers of the 5-HT-positive and TPH-positive cells were reduced by alcohol and nicotine treatment in a dose-dependent manner. Based on the results, it can be suggested that the pathogenesis of alcohol- and nicotine-induced neuropsychological disorders involves alcohol- and nicotine-induced suppression of 5-HT synthesis and TPH expression in raphe, and that this may be of particular relevance in the consumption of alcohol and nicotine during adolescence.

摘要

血清素（5-羟色胺，5-HT）与多种神经精神疾病的病理生理学有关。在本研究中，通过免疫组织化学研究了酒精和尼古丁对幼鼠背侧和中缝核中5-HT合成以及5-HT合成的限速酶色氨酸羟化酶（TPH）表达的影响。酒精和尼古丁处理以剂量依赖的方式减少了5-HT阳性和TPH阳性细胞的数量。基于这些结果，可以认为酒精和尼古丁诱导的神经心理障碍的发病机制涉及酒精和尼古丁诱导的中缝核中5-HT合成和TPH表达的抑制，并且这在青春期饮酒和吸烟过程中可能具有特别的相关性。

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