Rhim Yong-Taek, Kim Hong, Yoon Sung-Jin, Kim Sung-Soo, Chang Hyun-Kyung, Lee Taeck-Hyun, Lee Hee-Hyuk, Shin Min-Chul, Shin Mal-Soon, Kim Chang-Ju
Department of Exercise Physiology, Graduate School, Korea University, #1 5-Ka Anam-dong, Sungbuk-gu, Seoul 136-701, South Korea.
J Ethnopharmacol. 2007 Oct 8;114(1):38-43. doi: 10.1016/j.jep.2007.07.030. Epub 2007 Aug 3.
Acanthopanax senticosus Harms (AS) is classified into the family of Araliaceae. The plant has been used as an analeptic aid, which improves weakened physical status and strength. Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter and tryptophan hydroxylase (TPH) catalyzes the rate-f the raphe nuclei. These are associated with "central fatigue hypotheses" in the brain. In the present study, the effects of Acanthopanax senticosus on the time to exhaustion by treadmill exercise and on 5-HT synthesis and TPH expression in the dorsal raphe were investigated by immunohistochemistry. In the present results, Acanthopanax senticosus increased the time to exhaustion by treadmill running and it suppressed the exercise-induced increase of 5-HT synthesis and TPH expression. Acanthopanax senticosus was effective as caffeine for increasing the exhaustion time in treadmill running and for reducing the exercise-induced increase of 5-HT synthesis and TPH expression in the dorsal raphe. The present study shows that Acanthopanax senticosus reduces fatigue during exercise by the inhibition of exercise-induced 5-HT synthesis and TPH expression in the dorsal raphe.
刺五加（AS）属于五加科。该植物一直被用作提神辅助剂，可改善身体虚弱状况和增强体力。血清素（5-羟色胺，5-HT）是一种重要的神经递质，色氨酸羟化酶（TPH）催化中缝核的反应速率。这些与大脑中的“中枢疲劳假说”有关。在本研究中，通过免疫组织化学研究了刺五加对跑步机运动至疲劳时间以及对中缝背核中5-HT合成和TPH表达的影响。在本研究结果中，刺五加延长了跑步机跑步至疲劳的时间，并抑制了运动诱导的5-HT合成和TPH表达增加。刺五加在增加跑步机跑步疲劳时间以及减少运动诱导的中缝背核中5-HT合成和TPH表达增加方面与咖啡因效果相当。本研究表明，刺五加通过抑制运动诱导的中缝背核中5-HT合成和TPH表达来减轻运动期间的疲劳。
