Dworacka Marzena, Winiarska Hanna, Szymanska Malgorzata, Kuczynski Sebastian, Szczawinska Krystyna, Wierusz-Wysocka Bogna
Department of Pharmacology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland.
Int J Clin Pract Suppl. 2002 Jul(129):40-4.
In recent years a great deal of discussion has focused on postprandial hyperglycaemia as a risk factor for cardiovascular mortality. Routinely used parameters of metabolic control such as fasting plasma glucose (FPG) and HbA1c are not useful for determination of daily glucose excursions. 1,5-Anhydro-D-glucitol (1,5-AG) in human plasma has been proposed for several years as a short-term, retrospective marker of glycaemic control and seems to be the most suitable parameter for monitoring glucose excursions. The plasma level of 1,5-AG reflects acute episodes of hyperglycaemia more sensitively than HbA1c does and is correlated with FPG and postprandial hyperglycaemic peaks. The maximal glycaemic value observed in a patient ultimately determines the plasma 1,5-AG level. 1,5-AG could be helpful in detection of hyperglycaemic excursions, even in those patients with diabetes who self-monitor blood glucose and in those patients who are monitored routinely for FPG and HbA1c. In non-diabetic patients the plasma 1,5-AG level may serve as a screening marker for postprandial hyperglycaemia-associated cardiovascular risk.
近年来，大量讨论聚焦于餐后高血糖作为心血管疾病死亡率的危险因素。常规用于代谢控制的参数，如空腹血糖（FPG）和糖化血红蛋白（HbA1c），对于确定每日血糖波动并无用处。多年来，人体血浆中的1,5-脱水-D-葡萄糖醇（1,5-AG）一直被提议作为血糖控制的短期回顾性标志物，并且似乎是监测血糖波动最合适的参数。1,5-AG的血浆水平比HbA1c更敏感地反映高血糖急性发作，并且与FPG和餐后高血糖峰值相关。患者观察到的最大血糖值最终决定血浆1,5-AG水平。1,5-AG有助于检测血糖波动，即使在那些自我监测血糖的糖尿病患者以及那些常规监测FPG和HbA1c的患者中也是如此。在非糖尿病患者中，血浆1,5-AG水平可作为餐后高血糖相关心血管风险的筛查标志物。
