1,5-脱水-d-果糖代谢为 1,5-脱水-d-山梨醇。
Metabolism of 1,5-Anhydro-d-fructose to 1,5-Anhydro-d-glucitol.
机构信息
Joint Faculty of Veterinary Medicine Kagoshima University, Kagoshima, Japan.
SUNUS Co., Ltd., Kagoshima, Japan.
出版信息
In Vivo. 2023 May-Jun;37(3):1022-1027. doi: 10.21873/invivo.13176.
BACKGROUND/AIM: 1,5-Anhydro-d-fructose (1,5-AF, saccharide) and 1,5-anhydro-d-glucitol (1,5-AG) converted from 1,5-AF via the glycemic pathway have health benefits. However, this metabolism has not been sufficiently elucidated. To clarify the in vivo metabolism of 1,5-AF to 1,5-AG, porcine (blood kinetics) and human (urinary excretion) studies were conducted.
MATERIALS AND METHODS
Microminipigs were administrated 1,5-AF orally or intravenously. Blood samples were obtained to analyse the kinetics of 1,5-AF and 1,5-AG. Urine samples were collected from human subjects who had orally ingested 1,5-AF, and the amounts of 1,5-AF and 1,5-AG excreted in the urine were analysed.
RESULTS
In blood kinetics analysis, the time to the maximum concentration of 1,5-AF after intravenous administration was 0.5 h, whereas 1,5-AF was not observed after oral administration. The times to the maximum concentration of 1,5-AG after intravenous and oral administration were 1.5 h and 2 h, respectively. In urinary excretion, the concentration of 1,5-AG in urine rapidly increased after the administration of 1,5-AF, peaked at 2 h, whereas 1,5-AF was not detected.
CONCLUSION
1,5-AF was rapidly metabolized to 1.5-AG in vivo in swine and human.
背景/目的：1,5-脱水-D-呋喃果糖（1,5-AF，糖）和 1,5-脱水-D-山梨醇（1,5-AG）通过血糖途径从 1,5-AF 转化而来，对健康有益。然而，这种代谢尚未得到充分阐明。为了阐明 1,5-AF 向 1,5-AG 的体内代谢，进行了猪（血液动力学）和人（尿排泄）研究。
材料和方法
给微型猪口服或静脉内给予 1,5-AF。采集血样分析 1,5-AF 和 1,5-AG 的动力学。从口服摄入 1,5-AF 的人类受试者收集尿液样本，并分析尿液中排泄的 1,5-AF 和 1,5-AG 的量。
结果
在血液动力学分析中，静脉给药后 1,5-AF 的最大浓度时间为 0.5 小时，而口服给药后则未观察到 1,5-AF。静脉和口服给药后 1,5-AG 的最大浓度时间分别为 1.5 小时和 2 小时。在尿排泄中，1,5-AF 给药后 1,5-AG 的尿液浓度迅速增加，在 2 小时时达到峰值，而未检测到 1,5-AF。
结论
1,5-AF 在猪和人体内迅速代谢为 1.5-AG。
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