铜蓝蛋白对鸡胚和小鼠中AoPR8流感病毒感染的影响。
Effect of ceruloplasmin on AoPR8 influenza virus infection in embryonate eggs and mice.
作者信息
Tomas E, Samuel I
出版信息
Virologie. 1975;26(1):57-61.
PMID:1216690
Abstract
Inoculation to embryonate hen eggs and mice of AoPR8 influenza virus pre-incubated with ceruloplasmin (10(-7)-10(-6) M) results in a statistically significant decrease in the hemagglutinating titer of the virus, without changes in infectivity. This effect is ascribed to formation of a virus-ceruloplasmin complex, which probably interferes with both virus penetration and release of newly formed virus from the cell.
摘要
用铜蓝蛋白（10⁻⁷ - 10⁻⁶ M）预孵育的AoPR8流感病毒接种于鸡胚和小鼠后，病毒的血凝滴度在统计学上显著降低，而感染性无变化。这种效应归因于病毒 - 铜蓝蛋白复合物的形成，该复合物可能会干扰病毒的穿透以及新形成的病毒从细胞中的释放。
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