Samuel I, Tomas E
Virologie. 1975;26(2):117-23.
Three stages can be distinguished in the evolution of HA titer during Sendai virus multiplication in chorioallantoic membrane (CAM) fragments in relation to the age of CAM and conditions of inoculation and maintenance. Ceruloplasmin has an inhibitory effect on virus multiplication, more marked in the case of stationarily maintained CAM fragments and dependent on the relationship between the moment of ceruloplasmin addition and of virus inoculation. Maximum inhibition is achieved by inoculation of Sendai virus (1 Ha u) after 4 1/2-hour preincubation with ceruloplasmin (5 x 10(-7)M). The experimental data plead for the formation of a virus-ceruloplasmin complex able to inhibit both penetration and release of virus synthesized in the cell.
在绒毛尿囊膜（CAM）片段中，仙台病毒增殖过程中血凝素（HA）滴度的演变可根据CAM的年龄、接种和维持条件分为三个阶段。铜蓝蛋白对病毒增殖有抑制作用，在静止维持的CAM片段中更为明显，且取决于添加铜蓝蛋白和接种病毒的时间关系。在与铜蓝蛋白（5×10⁻⁷M）预孵育4.5小时后接种仙台病毒（1个血凝素单位）可实现最大抑制。实验数据支持形成一种病毒 - 铜蓝蛋白复合物，该复合物能够抑制细胞中合成的病毒的穿透和释放。
