肥胖：抑制饥饿 - Suppr

Obesity: keeping hunger at bay.

作者信息

Schwartz Michael W, Morton Gregory J

出版信息

Nature. 2002 Aug 8;418(6898):595-7. doi: 10.1038/418595a.

DOI:10.1038/418595a

PMID:12167841

Abstract

摘要

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Obesity: keeping hunger at bay.

Nature. 2002 Aug 8;418(6898):595-7. doi: 10.1038/418595a.

Gut hormone PYY(3-36) physiologically inhibits food intake.

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Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake.

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Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

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PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors.

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Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways.

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Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4695-700. doi: 10.1073/pnas.0306931101. Epub 2004 Mar 15.

Rapid rewiring of arcuate nucleus feeding circuits by leptin.

Science. 2004 Apr 2;304(5667):110-5. doi: 10.1126/science.1089459.

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Science. 2004 Nov 26;306(5701):1453-4. doi: 10.1126/science.306.5701.1453a.

Nat Neurosci. 2005 Oct;8(10):1289-91. doi: 10.1038/nn1548. Epub 2005 Sep 11.

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Obesity: keeping hunger at bay.

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