生理学：肠道激素PYY3 - 36是否会减少啮齿动物的食物摄入量？

Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

作者信息

Tschöp M, Castañeda T R, Joost H G, Thöne-Reineke C, Ortmann S, Klaus S, Hagan M M, Chandler P C, Oswald K D, Benoit S C, Seeley R J, Kinzig K P, Moran T H, Beck-sickinger A G, Koglin N, Rodgers R J, Blundell J E, Ishii Y, Beattie A H, Holch P, Allison D B, Raun K, Madsen K, Wulff B S, Stidsen C E, Birringer M, Kreuzer O J, Schindler M, Arndt K, Rudolf K, Mark M, Deng X Y, Whitcomb D C, Halem H, Taylor J, Dong J, Datta R, Culler M, Craney S, Flora D, Smiley D, Heiman M L

机构信息

Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA.

出版信息

Nature. 2004 Jul 8;430(6996):1 p following 165; discussion 2 p following 165. doi: 10.1038/nature02665.

DOI:10.1038/nature02665

PMID:15243972

Abstract

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.

摘要

巴特哈姆等人报告称，肠道肽激素PYY3 - 36可减少啮齿动物的食物摄入量和体重增加，这一发现被誉为可能为肥胖症提供一种新的治疗方法。然而，我们无法重复他们的结果。尽管这种差异的原因尚未确定，但一种有效的抗肥胖药物最终必须在一系列情况下产生效果。巴特哈姆等人的研究结果难以轻易重复这一事实，使人对基于施用PYY3 - 36的抗肥胖方法的潜在价值产生质疑。