Dundar B, Bozdag-Dundar O, Can-Eke B, Coban T, Iscan M, Buyukbingol E
Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Tandogan, Ankara, Turkey.
Pharmazie. 2002 Jul;57(7):438-41.
The general term "retinoids" refers to both naturally occurring as well as synthetic compounds which exhibit biological activity similar to vitamin A (retinol). Vitamin A and its two metabolites, retinaldehyde and retinoic acid, are fat-soluble unsaturated isoprenoids necessary for the growth, differentiation and maintenance of epithelial tissues. In this study, we have synthesized thiazolidinedione/imidazolidinedione compounds as retinoids. Their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels and superoxide anion formation were determined.
