Carballeira N M
Department of Chemistry, University of Puerto Rico, PO Box 23346, San Juan, Puerto Rico 00931-3346.
Prog Lipid Res. 2002 Nov;41(6):437-56. doi: 10.1016/s0163-7827(02)00005-x.
Methoxylated lipids have been reviewed emphasizing the alkylglycerol ethers and fatty acids bearing the methoxy group in the alkyl chain. The literature on methoxylated lipids and their derivatives has been divided into four main groups, namely 2-methoxylated alkyl glycerols, omega-methoxylated fatty acids, mid-chain methoxylated fatty acids, and alpha-methoxylated fatty acids. The natural occurrence, biological activity, and synthesis of this interesting group of lipids are discussed. Most of these compounds have been isolated from either bacterial or marine sources, but others are mainly of synthetic origin. Among the interesting biological activities displayed by these compounds the most important are antibacterial, antifungal, antitumor, and antiviral.
对甲氧基化脂质进行了综述，重点关注烷基甘油醚和在烷基链中带有甲氧基的脂肪酸。关于甲氧基化脂质及其衍生物的文献分为四个主要类别，即2-甲氧基化烷基甘油、ω-甲氧基化脂肪酸、中链甲氧基化脂肪酸和α-甲氧基化脂肪酸。讨论了这一有趣脂质类别的天然存在、生物活性和合成。这些化合物大多从细菌或海洋来源分离得到，但其他一些主要是合成来源。在这些化合物所表现出的有趣生物活性中，最重要的是抗菌、抗真菌、抗肿瘤和抗病毒活性。
